1,1-Dichlorohexadecane | 63415-61-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: 1,1-Dichlorohexadecane
• CAS: 63415-61-2
• 化学式: C₁₆H₃₂Cl₂
• 分子量: 295.3
• InChiKey: HLYSUDKSAQOMSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• [EN] SUBSTITUTED AMINO TRIAZOLES USEFUL AS HUMAN CHITINASE INHIBITORS<br/>[FR] TRIAZOLES AMINO-SUBSTITUÉS UTILES EN TANT QU'INHIBITEURS DE CHITINASE HUMAINE
  申请人：ONCOARENDI THERAPEUTICS SP Z O O

  公开号：WO2017037670A1

  公开（公告）日：2017-03-09

  Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.

  揭示了一种氨基三唑化合物，其带有一个被杂环环取代的哌啶环。这些化合物是酸性哺乳动物几丁质酶和几丁三糖酶的抑制剂。还公开了使用这些化合物治疗由过敏原引起的哮喘反应，以及急性和慢性炎症性疾病、自身免疫疾病、牙科疾病、神经系统疾病、代谢性疾病、肝脏疾病、多囊卵巢综合征、子宫内膜异位症和癌症的方法。
• [EN] 4, 6-DI (3,12-DIAZA-6, 9-DIAZONIADISPIRO [5.2.5.2] HEXANDECAN-1-YL) -2-METHYL-5-NITROPYRIMIDINE TETRACHLORIDE DIHYDROCHLORIDE HEXAHYDRATE FOR THE TREATMENT OF HERPETIC INFECTION AND A TOPICAL PHARMACEUTICAL COMPOSITION<br/>[FR] HEXAHYDRATE DE DICHLORHYDRATE DE TÉTRACHLORURE DE 4,6-DI(3,12-DIAZA-6,9-DIAZONIADISPIRO[5.2.5.2]HEXADÉCAN-1-YL)-2-MÉTHYL-5-NITROPYRIMIDINE UTILISÉ POUR POUR LE TRAITEMENT DE L'INFECTION HERPÉTIQUE ET COMPOSITION PHARMACEUTIQUE TOPIQUE
  申请人：LTD LIABILITY COMPANY NEARMEDIC PLUS

  公开号：WO2015167368A1

  公开（公告）日：2015-11-05

  The invention relates to the use of 4, 6-di(3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecan-1-yl)-2-methyl-5-nitropyrimidine tetrachloride dihydrochloride hexahydrate exhibiting activity against herpes virus, for the prevention and treatment of herpetic infections in humans and animals by topical administration.

  该发明涉及使用对单核病毒具有活性的4,6-二(3,12-二氮杂-6,9-二氮杂二螺[5.2.5.2]十六烷基)-2-甲基-5-硝基嘧啶四氯化物二盐酸盐六水合物，通过局部给药预防和治疗人类和动物的单纯疱疹感染。
• Metallocene catalysts for olefin polymerization and method of polymerizing olefins using the metallocene catalysts
  申请人：Samsung General Chemicals Co., Ltd.

  公开号：EP0994132A1

  公开（公告）日：2000-04-19

  The new metallocene catalysts according to the present invention are prepared by reacting a metallocene compound with a compound having at least two functional groups. The metallocene compound is a transition metal compound, which is coordinated with a main ligand such as cyclopentadienyl group, and an ancillary ligand. The functional groups in the compound are selected from the group consisting of a hydroxyl group, an alkyl or aryl magnesium halide, a thiol group, a primary amine group, a secondary amine group, a primary phosphorous group, a secondary phosphorous group, etc. The metallocene catalysts according to the present invention have a structure in which an ancillary ligand of a metallocene compound is bonded to the functional groups of a compound having at least two functional groups. A structure of the metallocene catalysts can be varied with the type of a metallocene compound and a compound having at least two functional groups, and the molar ratio of each reactant. The metallocene catalysts are employed with a co-catalyst for olefin polymerization. The co-catalyst is an organometallic compound, or a mixture of non-coordinated Lewis acid and alkylaluminium as it is well known in the art.

  本发明的新型茂金属催化剂是通过茂金属化合物与至少具有两个官能团的化合物反应制备的。茂金属化合物是一种过渡金属化合物，它与一种主配体（如环戊二烯基）和一种辅助配体配位。化合物中的官能团选自羟基、烷基或芳基卤化镁、硫醇基、伯胺基、仲胺基、伯磷基、仲磷基等。根据本发明的茂金属催化剂具有一种结构，其中茂金属化合物的辅助配体与具有至少两个官能团的化合物的官能团键合。茂金属催化剂的结构可以随茂金属化合物和至少具有两个官能团的化合物的类型以及各反应物的摩尔比而变化。茂金属催化剂与助催化剂一起用于烯烃聚合。助催化剂是一种有机金属化合物，或者是非配位路易斯酸和烷基铝的混合物，这在本领域是众所周知的。
• Metallocene catalysts for olefin polymerization and methog of polymerizing olefins using the metallocene catalysts
  申请人：Samsung General Chemicals Co., Ltd.

  公开号：EP2174963A2

  公开（公告）日：2010-04-14

  The new metallocene catalysts according to the present invention are prepared by reacting a metallocene compound with a compound having at least two functional groups. The metallocene compound is a transition metal compound, which is coordinated with a main ligand such as cyclopentadienyl group, and an ancillary ligand. The functional groups in the compound are selected from the group consisting of a hydroxyl group, an alkyl or aryl magnesium halide, a thiol group, a primary amine group, a secondary amine group, a primary phosphorous group, a secondary phosphorous group, etc. The metallocene catalysts according to the present invention have a structure in which an ancillary ligand of a metallocene compound is bonded to the functional groups of a compound having at least two functional groups. A structure of the metallocene catalysts can be varied with the type of a metallocene compound and a compound having at least two functional groups, and the molar ratio of each reactant. The metallocene catalysts are employed with a co-catalyst for olefin polymerization. The co-catalyst is an organometallic compound, or a mixture of non-coordinated Lewis acid and alkyl aluminium as it is well known in the art.

  本发明的新型茂金属催化剂是通过茂金属化合物与至少具有两个官能团的化合物反应制备的。茂金属化合物是一种过渡金属化合物，它与一种主配体（如环戊二烯基）和一种辅助配体配位。化合物中的官能团选自羟基、烷基或芳基卤化镁、硫醇基、伯胺基、仲胺基、伯磷基、仲磷基等组成的组。根据本发明的茂金属催化剂具有一种结构，其中茂金属化合物的辅助配体与具有至少两个官能团的化合物的官能团键合。茂金属催化剂的结构可以随茂金属化合物和至少具有两个官能团的化合物的类型以及各反应物的摩尔比而变化。茂金属催化剂与助催化剂一起用于烯烃聚合。助催化剂是一种有机金属化合物，或者是非配位路易斯酸和烷基铝的混合物，这在本领域是众所周知的。
• POLYISOCYANATE COMPOSITION AND ISOCYANATE POLYMER COMPOSITION
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2915803A1

  公开（公告）日：2015-09-09

  The present invention relates to a polyisocyanate composition comprising, on the basis of the total mass of the polyisocyanate composition, 97 weight % or more of a polyisocyanate, and 2.0 mass ppm or more and 1.0×104 mass ppm or less of a compound having at least one unsaturated bond in which the compound is a different compound from the polyisocyanate, or 5.0 mass ppm or more and 2.0×104 mass ppm or less of at least one inactive compound selected from the group consisting of a hydrocarbon compound, an ether compound, a sulfide compound, a halogenated hydrocarbon compound, a Si-containing hydrocarbon compound, a Si-containing ether compound, and a Si-containing sulfide compound.

  本发明涉及一种多异氰酸酯组合物，以该多异氰酸酯组合物的总质量为基准，该组合物包含 97 重量％或以上的多异氰酸酯，以及 2.0 质量 ppm 或以上且 1.0×104 质量 ppm 或以下的至少具有一个不饱和键的化合物，其中该化合物是与多异氰酸酯不同的化合物，或 5.0 质量 ppm 或以上且 2.0×104 质量 ppm 或以下的至少一种非活性化合物，该化合物选 自烃化合物、醚化合物、硫化物化合物、卤代烃化合物、含硅烃化合物、含硅醚化合物和含硅硫 化物组成的组。