5,5,11-trioxo-10,11-dihydro-dibenzo[b,f][1,4]thiazepine-8-carboxylic acid benzylamide | 688762-69-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: 5,5,11-trioxo-10,11-dihydro-dibenzo[b,f][1,4]thiazepine-8-carboxylic acid benzylamide
• 英文别名: N-benzyl-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide 5,5-dioxide；N-benzyl-6,11,11-trioxo-5H-benzo[b][1,4]benzothiazepine-3-carboxamide
• CAS: 688762-69-8
• 化学式: C₂₁H₁₆N₂O₄S
• 分子量: 392.435
• InChiKey: DLEOZQZMJVGFQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS<br/>[FR] MODULATEURS ALLOSTÉRIQUES DES PROTÉINES DU NOYAU DE L'HÉPATITE B
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2015138895A1

  公开（公告）日：2015-09-17

  ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

  摘要 本公开提供了部分具有对乙型肝炎病毒Cp具有变构效应的化合物。本文还提供了治疗病毒感染（如乙型肝炎）的方法，包括向需要的患者施用所述化合物。
• SULFAMOYLBENZAMIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST HBV INFECTION
  申请人：Guo Ju-Tao

  公开号：US20140206666A1

  公开（公告）日：2014-07-24

  Pharmaceutical compositions of the invention comprise sulfamoylbenzamide derivative useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.

  本发明的药物组合物包括磺胺基苯甲酰衍生物，作为前基因组RNA封装抑制剂，用于治疗乙型肝炎病毒（HBV）感染。
• Hepatitis B core protein allosteric modulators
  申请人：Indiana University Research and Technology Corporation

  公开号：US10183936B2

  公开（公告）日：2019-01-22

  The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

  本公开内容部分提供了对乙型肝炎病毒 Cp 具有异生效应特性的化合物。本文还提供了治疗病毒感染（如乙型肝炎）的方法，包括向有需要的患者施用所公开的化合物。
• HEPATITIS B CORE PROTEIN ALLOSTERIC MODULATORS
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY

  公开号：US20170015658A1

  公开（公告）日：2017-01-19

  The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
• US9399619B2
  申请人：——

  公开号：US9399619B2

  公开（公告）日：2016-07-26