1,5-bis-(3-methyl-benzothiazol-2-yl)-pentamethinium | 60387-94-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 1,5-bis-(3-methyl-benzothiazol-2-yl)-pentamethinium
• 英文别名: 3-methyl-2-[5-(3-methyl-3H-benzothiazol-2-ylidene)-penta-1,3-dienyl]-benzothiazolium；(2E)-3-methyl-2-[(2E,4E)-5-(3-methyl-1,3-benzothiazol-3-ium-2-yl)penta-2,4-dienylidene]-1,3-benzothiazole
• CAS: 60387-94-2
• 化学式: C₂₁H₁₉N₂S₂
• 分子量: 363.527
• InChiKey: BREIFVQIRDIHRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  60.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] CANCER CELL INHIBITORY DRUG AND CANCER STEM-CELL DETECTION PROBE<br/>[FR] MÉDICAMENT INHIBITEUR DE CELLULES CANCÉREUSES ET SONDE DE DÉTECTION DE CELLULES SOUCHES CANCÉREUSES
  申请人：CANON KK

  公开号：WO2014065439A1

  公开（公告）日：2014-05-01

  An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient.

  本发明的目的是提供一种癌细胞抑制药物，特别是一种癌干细胞抑制药物，或一种癌干细胞检测探针。本发明提供了一种包含至少一种以通式（1）表示的化合物作为活性成分的癌细胞抑制药物。
• Method of detecting cancer stem cell, method of screening cancer stem cell, and method of inhibiting cancer stem cell
  申请人：CANON KABUSHIKI KAISHA

  公开号：US10278965B2

  公开（公告）日：2019-05-07

  An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient

  本发明的目的是提供一种癌细胞抑制药物，特别是癌干细胞抑制药物或癌干细胞检测探针。本发明提供了一种癌细胞抑制药物，它包含至少一种通式（1）代表的化合物作为活性成分
• CANCER CELL INHIBITORY DRUG AND CANCER STEM-CELL DETECTION PROBE
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20150182518A1

  公开（公告）日：2015-07-02

  An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient.
• NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF
  申请人：BETH ISRAEL DEACONESS MEDICAL CENTER

  公开号：US20160263249A1

  公开（公告）日：2016-09-15

  The instant invention provides near-infrared fluorescent biological contrast agents and methods of using them.
• METHOD OF DETECTING CANCER STEM CELL, METHOD OF SCREENING CANCER STEM CELL, AND METHOD OF INHIBITING CANCER STEM CELL
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20170340622A1

  公开（公告）日：2017-11-30

  An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by general formula (1) as an active ingredient