N-((R)-2-oxopyrrolidin-3-yl)-3-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide | 1414378-46-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-((R)-2-oxopyrrolidin-3-yl)-3-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxamide
• 英文别名: N-[(3R)-2-oxopyrrolidin-3-yl]-3-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-4,5,6,7-tetrahydro-2-benzothiophene-1-carboxamide
• CAS: 1414378-46-3
• 化学式: C₂₃H₁₉Cl₃F₃N₃O₃S
• 分子量: 580.842
• InChiKey: LJDOEOMGYYTKNO-JGHKVMFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] PARASITICIDAL DIHYDROISOXAZOLE COMPOUNDS<br/>[FR] COMPOSÉS DIHYDROISOXAZOLE PARASITICIDES
  申请人：LILLY CO ELI

  公开号：WO2012158396A1

  公开（公告）日：2012-11-22

  Provided are dihydroisoxazole compounds I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling parasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. Also provided are compounds and processes useful for making the dihydroisoxazole compounds.

  提供了一种对动物和农业中的寄生虫具有控制作用的二氢异噁唑化合物。此外，还提供了通过向动物投与上述化合物或其药学上可接受的盐的有效量来控制动物寄生虫侵染的方法，以及使用上述化合物或其可接受的盐以及可接受的载体来控制寄生虫侵染的配方。还提供了用于制备二氢异噁唑化合物的化合物和工艺。
• [EN] PARASITICIDAL COMPOUNDS, METHODS, AND FORMULATIONS<br/>[FR] COMPOSÉS PARASITICIDES, PROCÉDÉS ET FORMULATIONS
  申请人：LILLY CO ELI

  公开号：WO2012155676A1

  公开（公告）日：2012-11-22

  Provided are dihydroisoxazole compounds useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling parasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. Also provided are compounds and processes useful for making the dihydroisoxazole compounds.

  提供了一种对动物和农业中的寄生虫具有控制作用的二氢异噁唑化合物。此外，还提供了一种通过向动物施用上述化合物或其药用盐的有效量来控制动物寄生虫侵染的方法，以及使用上述化合物或其可接受的盐以及可接受的载体来控制寄生虫侵染的配方。还提供了用于制备二氢异噁唑化合物的化合物和方法。
• [EN] DIHYDROISOXAZOLE COMPOUNDS, PARASITICIDAL USES AND FORMULATIONS THEREOF<br/>[FR] COMPOSÉS DE DIHYDROISOXAZOLE, UTILISATIONS ANTIPARASITAIRES ET PRÉPARATIONS ASSOCIÉES
  申请人：LILLY CO ELI

  公开号：WO2012155352A1

  公开（公告）日：2012-11-22

  Provided are dihydroisoxazole compounds useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling parasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier.

  提供了一种二氢异噁唑化合物，可用于控制动物和农业中的寄生虫。此外，还提供了一种通过向动物投与上述化合物或其药学上可接受的盐的有效量来控制动物寄生虫侵染的方法，以及使用上述化合物或其可接受盐和可接受载体的配方来控制寄生虫侵染。
• PARASITICIDAL DIHYDROISOXAZOLE COMPOUNDS
  申请人：An Zengyun

  公开号：US20130217699A1

  公开（公告）日：2013-08-22

  Provided are dihydroisoxazole compounds I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling parasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. Also provided are compounds and processes useful for making the dihydroisoxazole compounds.

  提供了一些二氢异噁唑化合物，可用于控制动物和农业中的寄生虫。此外，还提供了通过向动物投与上述化合物或其药学上可接受的盐的有效量来控制动物寄生虫感染的方法，以及使用上述化合物或其可接受盐和可接受载体来控制寄生虫感染的配方。还提供了有用于制造二氢异噁唑化合物的化合物和过程。
• Parasiticidal Dihydroisoxazole Compounds
  申请人：Eli Lilly and Company

  公开号：US20150072993A1

  公开（公告）日：2015-03-12

  Provided are dihydroisoxazole compounds I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling parasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. Also provided are compounds and processes useful for making the dihydroisoxazole compounds. wherein A is

  本发明提供了一种二氢异噁唑化合物，可用于控制动物和农业中的寄生虫。此外，还提供了一种通过向动物投与上述化合物或其药学上可接受的盐的有效量来控制动物寄生虫感染的方法，以及使用上述化合物或其可接受的盐和可接受的载体控制寄生虫感染的配方。还提供了制备二氢异噁唑化合物的化合物和过程。 其中A是...（未提供完整信息）