2-(1,8-Naphthyridin-2-yl)ethanol | 886362-87-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(1,8-Naphthyridin-2-yl)ethanol
• CAS: 886362-87-4
• 化学式: C₁₀H₁₀N₂O
• mdl: MFCD06738468
• 分子量: 174.2
• InChiKey: VUBXIPMQFDHNTL-UHFFFAOYSA-N

物化性质

• 沸点：
  329.1±27.0 °C(Predicted)
• 密度：
  1.241±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INTEGRIN TARGETING LIGANDS AND USES THEREOF
  申请人：Arrowhead Pharmaceuticals, Inc.

  公开号：US20210069337A1

  公开（公告）日：2021-03-11

  Compounds having affinity for integrins, the synthesis of these compounds, and the use of these compounds as ligands to facilitate the delivery of cargo molecules to cells expressing integrins are described. The described integrin targeting ligands have serum stability and affinity for αvβ3 integrin and/or αvβ5 integrin, and are suitable for conjugation to cargo molecules, such as such as oligonucleotide-based therapeutic agents (e.g., RNAi agents), to facilitate delivery of the cargo molecules to cells and tissues, such as tumor cells, that express integrin αvβ3, integrin αvβ5, or both integrin αvβ3 and integrin αvβ5. Compositions that include integrin targeting ligands and methods of use are also described.