(5S)-5-[[(5-methyl-1,2-oxazol-3-yl)amino]methyl]-3-[2,3,5-trifluoro-4-(4-oxo-2,3-dihydropyridin-1-yl)phenyl]-1,3-oxazolidin-2-one | 1112968-51-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (5S)-5-[[(5-methyl-1,2-oxazol-3-yl)amino]methyl]-3-[2,3,5-trifluoro-4-(4-oxo-2,3-dihydropyridin-1-yl)phenyl]-1,3-oxazolidin-2-one
• CAS: 1112968-51-0
• 化学式: C₁₉H₁₇F₃N₄O₄
• 分子量: 422.364
• InChiKey: QJOBMQBGZABQFC-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  87.9
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Antimicrobial ortho-Fluorophenyl Oxazolidinones For Treatment of Bacterial Infections
  申请人：Gordeev Mikhail Fedorovich

  公开号：US20090048305A1

  公开（公告）日：2009-02-19

  The present invention provides certain ortho-fluorophenyl oxazolidinones of the following formula I: or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

  本发明提供了以下结构式I的某些邻氟苯基噁唑啉酮化合物，或其药用可接受的盐或前药，这些化合物是抗菌剂，包含它们的药物组合物，以及使用这些化合物的方法和制备这些化合物的方法。
• Methods and Processes For Syntheses and Manufacture of Antimicrobial 1(Ortho-Fluorophenyl)dihydropyridones
  申请人：Wang Qiang

  公开号：US20100204477A1

  公开（公告）日：2010-08-12

  Provided herein are methods and processes for synthesis and manufacture of compounds of formula I: or its crystal forms, pharmaceutical acceptable salts, prodrugs, hydrates, or solvates thereof.

  本文提供了一种合成和制造化合物I的方法和过程：或其晶体形式、药用可接受盐、前药、水合物或溶剂化合物。
• [EN] METHODS AND PROCESSES FOR SYNTHESES AND MANUFACTURE OF ANTIMICROBIAL 1-(ORTHO-FLUOROPHENYL)DIHYDROPYRIDONES<br/>[FR] MÉTHODES ET PROCÉDÉS DE SYNTHÈSE ET DE FABRICATION DE 1-(ORTHO-FLUOROPHÉNYL)DIHYDROPYRIDONES ANTIMICROBIENNES
  申请人：MICURX PHARMACEUTICALS INC

  公开号：WO2010091272A1

  公开（公告）日：2010-08-12

  Provided herein are methods and processes for synthesis and manufacture of compounds of formula I: or its crystal forms, pharmaceutical acceptable salts, prodrugs, hydrates, or solvates thereof.

  本文提供了合成和制造公式I化合物的方法和过程：或其晶体形式，药用可接受盐，前药，水合物或其溶剂化物。
• ANTIMICROBIAL ORTHO-FLUOROPHENYL OXAZOLIDINONES FOR TREATMENT OF BACTERIAL INFECTIONS
  申请人：Gordeev Mikhail Fedorovich

  公开号：US20120190713A1

  公开（公告）日：2012-07-26

  The present invention provides certain ortho-fluorophenyl oxazolidinones of the following formula I: or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
• US8178683B2
  申请人：——

  公开号：US8178683B2

  公开（公告）日：2012-05-15