O-(3-Amino-2-chloro-propyl)-hydroxylamine; hydrochloride | 139526-91-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: O-(3-Amino-2-chloro-propyl)-hydroxylamine; hydrochloride
• CAS: 139526-91-3
• 化学式: C₃H₉ClN₂O*ClH
• 分子量: 161.031
• InChiKey: VAQQZJNDBMLWRG-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  N,N'-bis<(tert-butyloxy)carbonyl>-3-(aminooxy)-2-chloropropanamine 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以59.8%的产率得到O-(3-Amino-2-chloro-propyl)-hydroxylamine; hydrochloride
  参考文献：
  名称：

  2-Substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity

  摘要：

  1-Amino-3-(aminooxy)-2-propanol (6a) has been synthesized and found to inhibit rat liver ornithine decarboxylase (ODC) with an IC50 in the nanomolar range. Compound 6a served as a basis for the design of new enzyme inhibitors, which led to the identification of 3-(aminooxy)-2-fluoropropanamine (15) as a new powerful enzyme blocker. Compound 15 inhibited ODC at 3 times lower concentrations than 6a and 3-(aminooxy)propanamine (APA), and it was superior to APA as an antiproliferative agent in inhibiting the growth of human T24 bladder carcinoma cells in vitro.

  DOI：

  10.1021/jm00086a003