4-[(2-fluoro-5-methyl-phenyl)amino]-6-[trans-4-(3-oxo-piperazin-1-yl)-cyclohexyloxy]-7-methoxy-quinazoline | 1263311-03-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-[(2-fluoro-5-methyl-phenyl)amino]-6-[trans-4-(3-oxo-piperazin-1-yl)-cyclohexyloxy]-7-methoxy-quinazoline
• CAS: 1263311-03-0
• 化学式: C₂₆H₃₀FN₅O₃
• 分子量: 479.554
• InChiKey: RCZOLEQYGLHEJG-IYARVYRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.95
• 重原子数：
  35.0
• 可旋转键数：
  6.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  88.61
• 氢给体数：
  2.0
• 氢受体数：
  7.0

文献信息

• BICYCLIC HETEROCYCLES, DRUGS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR PRODUCTION THEREOF
  申请人：Himmelsbach Frank

  公开号：US20100022505A1

  公开（公告）日：2010-01-28

  The present invention relates to bicyclic heterocycles of general formula wherein R a , R b and R c are defined as in claim 1 , their tautomers, their stereoisomers, their mixtures and their salts, in particular their physiologically acceptable salts with inorganic or organic acids and bases, which have valuable pharmacological properties, in particular an inhibitory action on the signal transduction mediated by tyrosine kinases, their use for the treatment of illnesses, in particular of tumoral diseases and of benign prostatic hyperplasia (BPH), of diseases of the lung and of the airways, and the preparation thereof.

  本发明涉及一般式的双环杂环化合物 其中 R a ，R b 和R c 如权利要求中所定义， 它们的互变异构体，立体异构体，混合物和盐，特别是它们与无机或有机酸和碱形成的生理上可接受的盐，具有有价值的药理特性，特别是对酪氨酸激酶介导的信号传导具有抑制作用，它们用于治疗疾病，特别是肿瘤性疾病和良性前列腺增生（BPH），肺部和气道疾病，以及其制备。
• BICYCLISCHE HETEROCYCLEN, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2118075A1

  公开（公告）日：2009-11-18
• USE OF EPIDERMAL GROWTH FACTOR INHIBITORS IN THE TREATMENT OF VIRAL INFECTION
  申请人：The Regents of the University of California

  公开号：EP2373329A2

  公开（公告）日：2011-10-12
• Use of Epidermal Growth Factor Inhibitors in the Treatment of Viral Infection
  申请人：Koff Jonathan L.

  公开号：US20110236349A1

  公开（公告）日：2011-09-29

  The present invention provides methods of treating a viral infection in an individual. The methods generally involve administering to an individual an effective amount of an epidermal growth factor receptor (EGF-R) inhibitor.
• US7998949B2
  申请人：——

  公开号：US7998949B2

  公开（公告）日：2011-08-16