1-cyclopropyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol | 140367-10-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-cyclopropyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol
• 英文别名: 1-cyclopropyl-7-methoxy-3,4-dihydro-2H-naphthalen-1-ol
• CAS: 140367-10-8
• 化学式: C₁₄H₁₈O₂
• 分子量: 218.296
• InChiKey: ISJXMABLPMWFMU-UHFFFAOYSA-N

物化性质

• 沸点：
  358.5±37.0 °C(Predicted)
• 密度：
  1.195±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-cyclopropyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 反应 4.0h， 生成 3-(6-methoxy-1,2-dihydronaphthalen-4-yl)-N-n-propyl-n-propylamine hydrochloride
  参考文献：
  名称：

  Synthesis and dopamine receptor affinities of 1-aminoethylhetero-tetralines

  摘要：

  A series of 1-aminoethylhetero-tetralines 3-6, which can be considered as opened-structure analogues of previously studied dopaminergic compounds 2, were synthesized. In the binding studies, to evaluate D-1 and D-2 activity, no significant affinity was observed towards both dopaminergic receptors.

  DOI：

  10.1016/0223-5234(91)90129-b
• 作为产物：
  描述：

  7-甲氧基-1-萘满酮 、 环丙基溴化镁 以 四氢呋喃 为溶剂， 反应 5.0h， 以54%的产率得到1-cyclopropyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol
  参考文献：
  名称：

  Synthesis and dopamine receptor affinities of 1-aminoethylhetero-tetralines

  摘要：

  A series of 1-aminoethylhetero-tetralines 3-6, which can be considered as opened-structure analogues of previously studied dopaminergic compounds 2, were synthesized. In the binding studies, to evaluate D-1 and D-2 activity, no significant affinity was observed towards both dopaminergic receptors.

  DOI：

  10.1016/0223-5234(91)90129-b

文献信息

• N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY
  申请人：FARMITALIA CARLO ERBA S.r.l.

  公开号：EP0647222A1

  公开（公告）日：1995-04-12
• [EN] N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY<br/>[FR] N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE A ACTIVITE SEROTONINERGIQUE, DOPAMINERGIQUE ET ADRENERGIQUE
  申请人：FARMITALIA CARLO ERBA S.R.L.

  公开号：WO1994000441A1

  公开（公告）日：1994-01-06

  (EN) N(hetero)-aryl-N(hetero)-tetralinalkyl piperazine having serotoninergic, dopaminergic and adrenergic activity, the processes for their preparation and relative therapeutic compositions for the treatment of anxiety generated by depression, for the treatment of schizophrenia, cerebral ischemia, opium like and psycho stimulant substances abuse syndromes consciousness disorders such as senile dementia, vigilance and memory disorders. Parkinson's and Alzheimer's diseases and for the treatment of arterial hypertension.(FR) N(hétéro)-aryl-N(hétéro)-tétralin-alkyl-pipérazine à activité serotoninergique, dopaminergique et adrénergique, ses procédés de préparation, et compositions thérapeutiques associées destinées au traitement de l'angoisse provoquée par la dépression, au traitement de la schizophrénie, des accès ischémiques cérébraux, des syndromes dus à l'usage de substances psychostimulantes et opiacées, des troubles de la conscience tels que la démence sénile et les troubles de la vigilance et de la mémoire, et des maladies de Parkinson et d'Alzheimer, ainsi qu'au traitement de l'hypertension artérielle.