9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-[1,4]oxazino[3,4-a]isoquinoline-3t-carboxylic acid dimethylamide | 67025-74-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-[1,4]oxazino[3,4-a]isoquinoline-3t-carboxylic acid dimethylamide
• CAS: 67025-74-5
• 化学式: C₁₇H₂₄N₂O₄
• 分子量: 320.389
• InChiKey: DNQJSFXIVTXPPW-BBRMVZONSA-N

反应信息

• 作为产物：
  描述：

  9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-[1,4]oxazino[3,4-a]isoquinoline-3t-carboxylic acid 、 二甲胺 生成 9,10-dimethoxy-(11br)-1,3,4,6,7,11b-hexahydro-[1,4]oxazino[3,4-a]isoquinoline-3t-carboxylic acid dimethylamide
  参考文献：
  名称：

  A series of hexahydro[1,4]oxazino[3,4-a]isoquinolines as potential neuroleptics

  摘要：

  The synthesis and stereochemistry of trans-N,N-diethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro[1,4]oxazino[3,4-a]isoquinoline-3-carboxamide hydrochloride (16) and a series of analogues are described. 16 and its (+) isomer had neuroleptic properties in the Sidman avoidance test in gerbils. A few closely related amides of the trans series were active but cis amides were inactive as neuroleptics.

  DOI：

  10.1021/jm00206a013