8-[(dibenzylamino)-methyl]-7,8-dihydro-3H-1,6,9-trioxa-3-aza-cyclopenta[a]-naphthalen-2-one | 474391-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 8-[(dibenzylamino)-methyl]-7,8-dihydro-3H-1,6,9-trioxa-3-aza-cyclopenta[a]-naphthalen-2-one
• 英文别名: 8-[(dibenzylamino)methyl]-7,8-dihydro-3H-[1,4]dioxino[2,3-g][1,3]benzoxazol-2-one
• CAS: 474391-36-1
• 化学式: C₂₄H₂₂N₂O₄
• 分子量: 402.45
• InChiKey: PUUBAMWDSGGIIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  60
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one
  申请人：Wyeth

  公开号：US20030073697A1

  公开（公告）日：2003-04-17

  Compounds of the formula 1 useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced pychoses and dyskinesias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addiction to ethanol, nicotine or cocaine and related illnesses.

  公式为1的化合物，用于治疗多巴胺系统疾病，如精神分裂症，情感性精神障碍，双相情感障碍，帕金森病，L-DOPA诱导的精神病和运动障碍，抽动症，高泌乳素血症以及药物成瘾的治疗，如对乙酰酒精，尼古丁或可卡因成瘾及相关疾病的治疗。
• US6800648B2
  申请人：——

  公开号：US6800648B2

  公开（公告）日：2004-10-05
• [EN] ANTIPSYCHOTIC AMINOMETHYL DERIVATIVES OF 7,8-DIHYDRO-3H-1,6,9-TRIOXA-3-AZA-CYCLOPENTA[a]NAPHTHALEN-2-ONE<br/>[FR] DERIVES AMINOMETHYLE DE 7,8-DIHYDRO-3H-1,6,9-TRIOXA-3-AZA-CYCLOPENTA[A]NAPHTALENE-2-ONE UTILES EN TANT QU'ANTIPSYCHOTIQUES
  申请人：WYETH CORP

  公开号：WO2002088142A1

  公开（公告）日：2002-11-07

  Compounds of the formula (I) useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced psychoses and dyskinesias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addiction to ethanol, nicotine or cocaine and related illnesses.