Sodium;3-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy]carbonylbenzenesulfonate | 36570-50-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Sodium;3-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy]carbonylbenzenesulfonate
• CAS: 36570-50-0
• 化学式: C28H31NaO9S
• 分子量: 566.6
• InChiKey: RWFZSORKWFPGNE-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.67
• 重原子数：
  39
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  167
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Foam-Forming composition
  申请人：Ferring International Center S.A.

  公开号：EP1810666A1

  公开（公告）日：2007-07-25

  The present invention relates to a novel foam-forming composition suitable for rectal administration of locally-acting pharmaceutically active ingredients, and the product adapted to administer said foam-forming composition. Also, the present invention relates to a method for its preparation. According to the present invention a foam-forming composition is provided which exhibits a high expansion ratio and at the same time conferring optimal appearance of the formed foam to allow sufficient contact time of the active to the target site in the intestine in order to obtain optimal local effect. The composition according to the present inventions provides superior properties for the treatment of rectal diseases.

  本发明涉及一种适用于局部作用药物活性成分直肠给药的新型泡沫形成组合物，以及适用于给药所述泡沫形成组合物的产品。此外，本发明还涉及一种制备方法。根据本发明，提供了一种泡沫形成组合物，该组合物具有较高的膨胀率，同时所形成的泡沫具有最佳的外观，使活性成分与肠道中的目标部位有足够的接触时间，以获得最佳的局部效果。本发明的组合物具有治疗直肠疾病的优异性能。
• EP1981480A1
  申请人：——

  公开号：EP1981480A1

  公开（公告）日：2008-10-22
• FOAM-FORMING COMPOSITION
  申请人：Boutignon Francois Jean-Louis Jerome

  公开号：US20100166672A1

  公开（公告）日：2010-07-01

  The present invention relates to a novel foam-forming composition suitable for rectal administration of locally-acting pharmaceutically active ingredients, and the product adapted to administer said foam-forming composition. Also, the present invention relates to a method for its preparation. According to the present invention a foam-forming composition is provided which exhibits a high expansion ratio and at the same time conferring optimal appearance of the formed foam to allow sufficient contact time of the active to the target site in the intestine in order to obtain optimal local effect. The composition according to the present inventions provides superior properties for the treatment of rectal diseases.
• US8206688B2
  申请人：——

  公开号：US8206688B2

  公开（公告）日：2012-06-26
• [EN] FOAM-FORMING COMPOSITION<br/>[FR] COMPOSITION MOUSSANTE
  申请人：DISPHAR INT BV

  公开号：WO2007082698A1

  公开（公告）日：2007-07-26

  [EN] The present invention relates to a novel foam-forming composition suitable for rectal administration of locally-acting pharmaceutically active ingredients, and the product adapted to administer said foam-forming composition. Also, the present invention relates to a method for its preparation. According to the present invention a foam-forming composition is provided which exhibits a high expansion ratio and at the same time conferring optimal appearance of the formed foam to allow sufficient contact time of the active to the target site in the intestine in order to obtain optimal local effect. The composition according to the present inventions provides superior properties for the treatment of rectal diseases.
  [FR] La présente invention concerne une nouvelle composition moussante conçue pour l'administration par voie rectale d'agents pharmaceutiquement actifs à action locale. L'invention concerne également le produit destiné à administrer la composition moussante ainsi qu'un procédé pour la préparer. La composition moussante selon l'invention fait preuve d'un taux d'expansion élevé et confère en même temps un aspect optimal à la mousse formée permettant à l'agent actif d'être en contact avec le site cible dans l'intestin pendant une durée suffisante pour obtenir un effet local optimal. Ladite composition offre des qualités supérieures pour le traitement de maladies affectant le rectum.