2,4-Dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide | 1207176-13-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,4-Dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxamide
• 英文别名: 2,4-dioxo-1H-quinazoline-7-carboxamide
• CAS: 1207176-13-3
• 化学式: C₉H₇N₃O₃
• 分子量: 205.17
• InChiKey: ZTWORBCXCHMESF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] PROLYL HYDROXYLASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PROLYL HYDROXYLASE
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2010059549A1

  公开（公告）日：2010-05-27

  The invention described herein relates to certain 2,4-dioxo-l,2,3,4-tetrahydro-7- quinazolinecarboxamide derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

  本发明涉及某些公式（I）的2,4-二氧代-1,2,3,4-四氢-7-喹唑啉羧酰胺衍生物，这些衍生物是HIF脯氨酸羟化酶的拮抗剂，对于治疗受益于抑制该酶的疾病是有用的，贫血就是一个例子。
• [EN] SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF<br/>[FR] ACIDES HYDROXAMIQUES SUBSTITUÉS ET LEURS UTILISATIONS
  申请人：MILLENNIUM PHARM INC

  公开号：WO2012054332A1

  公开（公告）日：2012-04-26

  This invention provides compounds of formula (I): wherein R1a, R1b, Ra, R2a, R2b, R1, and X have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.