4-(1,2,4-Oxadiazol-5-YL)piperidine | 1247631-90-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(1,2,4-Oxadiazol-5-YL)piperidine
• 英文别名: 5-piperidin-4-yl-1,2,4-oxadiazole
• CAS: 1247631-90-8
• 化学式: C₇H₁₁N₃O
• mdl: MFCD11042735
• 分子量: 153.18
• InChiKey: BKYBBCQYORLQOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  51
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS
  申请人：Genzyme Corporation

  公开号：EP3080108A1

  公开（公告）日：2016-10-19
• [EN] TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS<br/>[FR] INHIBITEURS DE KINASES APPARENTÉES À LA TROPOMYOSINE (TRK)
  申请人：GENZYME CORP

  公开号：WO2015089139A1

  公开（公告）日：2015-06-18

  Tropomyosin-related kinase inhibitors (Trk inhibitors) are small molecule compounds useful in the treatment of disease. Trk inhibitors can be used as pharmaceutical agents and in pharmaceutical compositions. Trk inhibitors are useful in the treatment of inflammatory diseases, autoimmune disease, defects of bone metabolism and/or cancer, and are particularly useful in the treatment of osteoarthritis (OA), pain, and pain associated with OA. Trk inhibitors are also useful for inhibiting tropomyosin-related kinase A (TrkA), tropomyosin-related kinase B (TrkB), tropomyosin-related kinase C (TrkC), and/or c-FMS (the cellular receptor for colony stimulating factor-1 (CSF-1)).