2-(4-methoxyphenyl)-1-methylpiperazine | 1018610-80-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-methoxyphenyl)-1-methylpiperazine
• CAS: 1018610-80-4
• 化学式: C₁₂H₁₈N₂O
• 分子量: 206.288
• InChiKey: OAUORYZPTXUCIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-bromo-2,2,4,6,7-pentamethyl-1-benzofuran-3(2H)-one 、 2-(4-methoxyphenyl)-1-methylpiperazine 在 palladium diacetate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 以74%的产率得到5-[3-(4-methoxyphenyl)-4-methylpiperazin-1-yl]-2,2,4,6,7-pentamethyl-1-benzofuran-3(2H)-one
  参考文献：
  名称：

  Discovery of Benzofuran Derivatives that Collaborate with Insulin-Like Growth Factor 1 (IGF-1) to Promote Neuroprotection

  摘要：

  A series of benzofuran derivatives with neuroprotective activity in collaboration with IGF-1 was discovered using a newly developed cell-based assay involving primary neural cells prepared from rat hippocampal and cerebral cortical tissues. A structure activity relationship study identified compound 8 as exhibiting potent activity and brain penetrability. An in vitro pharmacological study demonstrated that although IGF-1 and 8 individually exhibited the neuroprotective effect, the latter acted in collaboration with IGF-1 to enhance neuroprotective activity.

  DOI：

  10.1021/acs.jmedchem.6b00191

文献信息

• Benzofuran derivatives
  申请人：Tsukamoto Tetsuya

  公开号：US20100234357A1

  公开（公告）日：2010-09-16

  The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring; R 1 and R 2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R 3 and R 4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R 5 to R 7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, or a salt thereof.

  本发明提供了一种由以下式（I）表示的化合物： 其中： 环A代表可选择地取代的哌嗪环、可选择地取代的吗啉环或可选择地取代的同环丙二胺环； R1和R2彼此相同或不同，代表氢原子或可选择地取代的较低烷基； R3和R4彼此相同或不同，代表氢原子或卤代或非卤代的较低烷基； R5到R7彼此相同或不同，代表氢原子、羟基、可选择地取代的较低烷基、可选择地取代的较低烯基、可选择地取代的较低烷氧基、可选择地取代的环烷基、可选择地取代的芳基、可选择地取代的芳香杂环、可选择地取代的氨基或酰基；和 代表单键或双键，或其盐。
• BENZOFURAN DERIVATIVES
  申请人：Tsukamoto Tetsuya

  公开号：US20120046277A1

  公开（公告）日：2012-02-23

  The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted bromopiperazine ring; R 1 and R 2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R 3 and R 4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R 3 to R 7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloakyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, wherein R 2 and R 3 do not exist when carbon atoms respectively adjacent to R 2 : and R 3 form a double bond, and there is no case where all of R 1 to R 7 are hydrogen atoms, and R 1 and R 2 ; may form a ring together with an adjacent carbon atom; or a salt thereof.

  本发明提供了以下式(I)所表示的化合物：其中：环A表示可选取代的哌嗪环、可选取代的吗啡环或可选取代的溴代哌嗪环；R1和R2相同或不同，表示氢原子或可选取代的较低烷基；R3和R4相同或不同，表示氢原子或卤代或非卤代的较低烷基；R3到R7相同或不同，表示氢原子、羟基、可选取代的较低烷基、可选取代的较低烯基、可选取代的较低烷氧基、可选取代的环烷基、可选取代的芳基、可选取代的芳香族杂环环、可选取代的氨基或酰基；表示单键或双键，其中当R2和R3分别相邻的碳原子形成双键时，R2和R3不存在，且不存在R1到R7全为氢原子的情况，R1和R2可以与相邻碳原子共同形成环；或其盐。
• AMINOPYRIDINE DERIVATIVE
  申请人：Tsukamoto Tetsuya

  公开号：US20130005710A1

  公开（公告）日：2013-01-03

  The present invention provides a novel aminopyridine derivative that is excellent in pharmaceutical effects such as a neuroprotective effect, a neurogenesis or nerve regeneration promoting effect, and a cognitive function improving effect and, preferably, is low toxic and delivered at a high rate to the central nervous system. Specifically, the present invention provides a compound represented by the formula (I), wherein ring A represents a monocyclic aromatic hydrocarbon ring or the like; ring B may further have a substituent(s); ring D represents a monocyclic aromatic hydrocarbon ring or the like; L represents a bond, or a methylene group or the like; X represents —NRa- or the like, wherein Ra represents a hydrogen atom or the like; n represents 1 or 2; and R 1 to R 3 each represent a hydrogen atom or the like, wherein ring A and ring D each may be condensed with another ring to form a condensed ring which may have a substituent(s), and ring A-L- in the formula (I) may be bonded to X, provided that when ring A is pyrazole which may be substituted and ring D is benzene which may be substituted, L is a bond; or a salt thereof.

  本发明提供了一种新型的氨基吡啶衍生物，其在药理作用方面表现出色，如神经保护作用、神经发生或神经再生促进作用和认知功能改善作用，并且最好是低毒性并以高速递送到中枢神经系统。具体而言，本发明提供了一种由式(I)表示的化合物，其中环A表示单环芳香烃环或类似物；环B可以进一步具有取代基；环D表示单环芳香烃环或类似物；L表示键合或亚甲基基团或类似物；X表示-NRa-或类似物，其中Ra表示氢原子或类似物；n表示1或2；R1至R3各自表示氢原子或类似物，其中环A和环D各自可以与另一个环融合形成融合环，该融合环可以具有取代基，式(I)中的环A-L-可以与X键合，但当环A为可能被取代的吡唑环，环D为可能被取代的苯环时，L为键合；或其盐。
• US8288390B2
  申请人：——

  公开号：US8288390B2

  公开（公告）日：2012-10-16
• US8957069B2
  申请人：——

  公开号：US8957069B2

  公开（公告）日：2015-02-17