4-(1,2,4-Oxadiazol-3-YL)piperidine | 1250117-85-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(1,2,4-Oxadiazol-3-YL)piperidine
• 英文别名: 3-piperidin-4-yl-1,2,4-oxadiazole
• CAS: 1250117-85-1
• 化学式: C₇H₁₁N₃O
• 分子量: 153.18
• InChiKey: ORFXJJVVHVUFCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  51
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] HETEROARYL SULTAM DERIVATIVES AS RORc MODULATORS<br/>[FR] DÉRIVÉS D'HÉTÉROARYLE SULTAME UTILISÉS EN TANT QUE MODULATEURS DE RORC
  申请人：HOFFMANN LA ROCHE

  公开号：WO2015104353A1

  公开（公告）日：2015-07-16

  (I) Compounds of the formula I or a pharmaceutical salt thereof, wherein m, n, q, r, A, W, X1, X2, X3, X4, Y,, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

  化合物的公式I或其药用盐，其中m、n、q、r、A、W、X1、X2、X3、X4、Y、Z、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10和R11的定义如本文所述。还公开了制备这些化合物的方法，以及将这些化合物用于治疗炎症性疾病如关节炎的方法。
• [EN] ARYL SULTAM DERIVATIVES AS RORc MODULATORS<br/>[FR] DÉRIVÉS ARYL SULTAMES EN TANT QUE MODULATEURS DE RORC
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014009447A1

  公开（公告）日：2014-01-16

  Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

  化合物的公式（I），或其药用盐，其中m、n、p、q、r、A、W、X1、X2、X3、X4、Y、Z、R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11和R12如本文所定义。还披露了制备这些化合物的方法以及将这些化合物用于治疗炎症性疾病如关节炎的方法。
• INDAZOLE- AND PYRROLOPYRIDINE-DERIVATIVE AND PHARMACEUTICAL USE THEREOF
  申请人：Mizuno Kazuhiro

  公开号：US20140057895A1

  公开（公告）日：2014-02-27

  The present invention relates to a novel indazole- or pyrrolopyridine-derivative comprising a 5 membered heterocyclic substituent at 1 position thereof which has an agonistic action or a partial agonistic action against serotonin-4 receptor, and a pharmaceutical composition comprising the same.

  本发明涉及一种新型吲唑或吡咯吡啶衍生物，其在1位具有一个5成员杂环取代基，具有对5-羟色胺-4受体的激动作用或部分激动作用，以及包含该衍生物的药物组合物。
• US6107313A
  申请人：——

  公开号：US6107313A

  公开（公告）日：2000-08-22
• [EN] PIPERIDYLOXADIAZOLES AS DOPAMINE RECEPTOR ANTAGONISTS<br/>[FR] PIPERIDYLOXADIAZOLES UTILISES COMME ANTAGONISTES DURECEPTEUR DE LA DOPAMINE
  申请人：COMBICHEM INC

  公开号：WO2000020414A1

  公开（公告）日：2000-04-13

  This invention provides a novel class of oxadiazolyl piperidines which exhibit a high binding affinity for dopamine ligands. The compounds of the invention display selectivity for the dopamine D4 receptor over the dopamine D2 receptor. Preferably, these compounds act as dopamine antagonists, which are useful in the treatment of psychotic disorders.