1,12-dimethyl-6,7-dihydrotribenzo[e,i,m][1,4,7,12]dioxadiazacyclotetradecine | 1160784-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 1,12-dimethyl-6,7-dihydrotribenzo[e,i,m][1,4,7,12]dioxadiazacyclotetradecine
• 英文别名: 13,26-Dimethyl-18,21-dioxa-2,11-diazatetracyclo[20.4.0.04,9.012,17]hexacosa-1(26),2,4,6,8,10,12,14,16,22,24-undecaene
• CAS: 1160784-56-4
• 化学式: C₂₄H₂₂N₂O₂
• 分子量: 370.451
• InChiKey: HONVXEQPFLWISU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  43.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-[[2-[(2-Hydroxy-6-methylphenyl)iminomethyl]phenyl]methylideneamino]-3-methylphenol 、 1,2-二溴乙烷 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 4.0h， 生成 1,12-dimethyl-6,7-dihydrotribenzo[e,i,m][1,4,7,12]dioxadiazacyclotetradecine
  参考文献：
  名称：

  Physicochemical and biological characterization of novel macrocycles derived from o-phthalaldehyde

  摘要：

  A series of novel macrocyclic compounds were synthesized by the condensation of o-phthalaldehyde with aromatic amino alcohols followed by treatment with 1,2-dibromoethane or 1,3-dibromopropane in non-template method. The structural features of the isolated macrocycles have been determined from the microanalytical, IR, H-1, C-13 NMR and mass spectral studies. Antimicrobial activities of these macrocyclic compounds were tested against the Gram-positive (Bacillus subtilis, Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae) bacteria and found to exhibit potential antibacterial activity. The macrocycles were also tested in vitro to evaluate their activity against fungi, namely, Aspergillus flavus (A. flavus) and Fusarium species. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.09.035