4-(4,9-dihydro-10-oxo-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-piperidinecaproic acid | 727354-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环七噻吩
• 英文名称: 4-(4,9-dihydro-10-oxo-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-piperidinecaproic acid
• 英文别名: 6-[4-(8-Oxo-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene)piperidin-1-yl]hexanoic acid
• CAS: 727354-74-7
• 化学式: C₂₄H₂₇NO₃S
• 分子量: 409.549
• InChiKey: YXZSZKAHBJNUSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  85.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Piperidine compounds, method for preparation thereof, and a pharamceutical composition comprising the same
  申请人：HOKURIKU PHARMACEUTICAL CO., LTD.

  公开号：EP0451772A1

  公开（公告）日：1991-10-16

  Novel piperidine compounds represented by the following formula (I): wherein Y represents an alkylene group having 1 to 7 carbon atoms; A is a group represented by formula I-a or formula I-b: wherein X represents -CH₂-S- or -S-; and R represents a hydrogen atom or a lower alkyl group with a proviso that A is a group represented by formula I-a, or R represents a hydrogen atom with a proviso that A is a group represented by formula I-b and pharmacologically acceptable salts thereof are disclosed. Also disclosed are a method for preparing the same; a pharmaceutical composition comprising the same; an antiallergic agent and an agent for bronchial asthma comprising the same; and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.

  本发明公开了以下式子（I）所表示的新型哌啶化合物：其中，Y代表具有1至7个碳原子的烷基；A是由式子I-a或式子I-b表示的基团：其中，X代表-CH₂-S-或-S-；R代表氢原子或较低的烷基，但在A是由式子I-a表示的基团时，R代表氢原子；在A是由式子I-b表示的基团时，R代表氢原子，其药理学上可接受的盐也被揭示。本发明还公开了一种制备该化合物的方法；包含该化合物的制药组合物；包含该化合物的抗过敏剂和支气管哮喘剂；以及通过给予该化合物进行治疗过敏性疾病或支气管哮喘的方法。