1-benzyl-5,7-dichloro-3-propyl-1H-quinazoline-2,4-dione | 1000860-93-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-benzyl-5,7-dichloro-3-propyl-1H-quinazoline-2,4-dione
• 英文别名: 1-Benzyl-5,7-dichloro-3-propylquinazoline-2,4-dione
• CAS: 1000860-93-4
• 化学式: C₁₈H₁₆Cl₂N₂O₂
• 分子量: 363.243
• InChiKey: BLJRPXNYJIEHFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NOVEL SUBSTITUTED-1-H-QUINAZOLINE-2,4-DIONE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Seong Churlmin

  公开号：US20090203708A1

  公开（公告）日：2009-08-13

  Disclosed herein are novel substituted-1H-quinazoline-2,4-dione derivatives, a preparation method thereof, and a pharmaceutical composition containing the same. The novel substituted-1H-quinazoline-2,4-dione derivatives are excellent in binding affinity and selectivity for 5-HT6 receptors over other receptors, inhibit serotonin(5-HT)-stimulated cAMP accumulation, and disrupt apomorphine(2 mg/kg, i.p.)-induced hyperactivity in rats. Thanks to these effects, the derivatives are useful in the treatment of 5-HT6 receptor-related central nervous system diseases.

  本文披露了一种新型的取代-1H-喹唑啉-2,4-二酮衍生物，其制备方法以及含有该衍生物的药物组合物。这种新型的取代-1H-喹唑啉-2,4-二酮衍生物在与其他受体相比对5-HT6受体的结合亲和力和选择性方面表现出色，抑制5-羟色胺（5-HT）刺激的cAMP积累，并破坏大鼠中阿波莫啡（2 mg/kg，i.p.）诱导的过度活动。由于这些效果，这些衍生物在治疗与5-HT6受体相关的中枢神经系统疾病中非常有用。
• PROCESS FOR PRODUCTION OF IMIDAZOTHIAZOLE DERIVATIVE
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1908766A1

  公开（公告）日：2008-04-09

  Disclosed is a process for producing an imidazothiazole derivative of formula (I) useful as an intermediate for the production of carbapenem derivatives having potent antimicrobial activity and a broad antimicrobial spectrum, that is, a novel method for nicotinoylating an imidazo[5,1-b]thiazole ring at its 7-position. The process comprises reacting a compound of formula (II) with a compound of formula (III).

  本文揭示了一种生产式（I）的咪唑噻唑衍生物的过程，该衍生物可用作生产具有强大抗微生物活性和广泛抗微生物谱的卡巴比林衍生物的中间体，即在其7位点对咪唑[5,1-b]噻唑环进行烟酰化的新方法。该过程包括将式（II）的化合物与式（III）的化合物反应。
• Process for Producing Imidazothiazole Derivatives
  申请人：Kubota Dai

  公开号：US20090036685A1

  公开（公告）日：2009-02-05

  Disclosed is a process for producing an imidazothiazole derivative of formula (I) useful as an intermediate for the production of carbapenem derivatives having potent antimicrobial activity and a broad antimicrobial spectrum, that is, a novel method for nicotinoylating an imidazo[5,1-b]thiazole ring at its 7-position. The process comprises reacting a compound of formula (II) with a compound of formula (III).

  本发明揭示了一种制备公式（I）的咪唑噻唑衍生物的方法，该方法可作为头孢烯类衍生物的中间体，具有强大的抗微生物活性和广谱的抗微生物谱，即在其7位处对咪唑[5,1-b]噻唑环进行新型烟酰化的方法。该方法包括将公式（II）的化合物与公式（III）的化合物反应。
• NOVEL SUBSTITUTED-1H-QUINAZOLINE-2,4-DIONE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP2035406A1

  公开（公告）日：2009-03-18
• EP2035406A4
  申请人：——

  公开号：EP2035406A4

  公开（公告）日：2009-08-05