{3,5-Bis-[4-(3,5-dimethoxy-benzoyl)-phenoxy]-phenyl}-(4-fluoro-phenyl)-methanone | 915033-66-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: {3,5-Bis-[4-(3,5-dimethoxy-benzoyl)-phenoxy]-phenyl}-(4-fluoro-phenyl)-methanone
• CAS: 915033-66-8
• 化学式: C₄₃H₃₃FO₉
• 分子量: 712.728
• InChiKey: VHWDQQADHBUZCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.14
• 重原子数：
  53.0
• 可旋转键数：
  14.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  106.59
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  5-(2-(4-fluorophenyl)-[1,3]dioxolan-2-yl)-benzene-1,3-diol 、 {3,5-Bis-[4-(3,5-dimethoxy-benzoyl)-phenoxy]-phenyl}-(4-fluoro-phenyl)-methanone 在 sodium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以48%的产率得到(4-{3-(4-{3,5-Bis-[4-(3,5-dimethoxy-benzoyl)-phenoxy]-benzoyl}-phenoxy)-5-[2-(4-fluoro-phenyl)-[1,3]dioxolan-2-yl]-phenoxy}-phenyl)-{3,5-bis-[4-(3,5-dimethoxy-benzoyl)-phenoxy]-phenyl}-methanone
  参考文献：
  名称：

  A convergent route to poly(phenyl ketone ether) dendrons

  摘要：

  A series of poly(phenyl ketone) dendrons have been constructed using a convergent strategy. An aryl fluoro-substituent is deactivated towards nucleophilic substitution by protection of a para-ketone as an acetal. This allows coupling to an activated aryl fluoride. Subsequent deprotection of the acetyl group then activates the first fluoro-substituent and allows the next generation of the dendron to be added. The synthesis of higher generations is complicated by a scrambling reaction, which lowers the yields. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.08.012
• 作为产物：
  描述：

  (4-氟-苯基)-(3,5-二甲氧基-苯基)-甲酮 在 三氟甲磺酸三甲基硅酯 、 三溴化硼 、 sodium carbonate 、 对甲苯磺酸 、 三氟乙酸 作用下， 以 乙醚 、 二甲基亚砜 、 丙酮 为溶剂， 反应 33.0h， 生成 {3,5-Bis-[4-(3,5-dimethoxy-benzoyl)-phenoxy]-phenyl}-(4-fluoro-phenyl)-methanone
  参考文献：
  名称：

  A convergent route to poly(phenyl ketone ether) dendrons

  摘要：

  A series of poly(phenyl ketone) dendrons have been constructed using a convergent strategy. An aryl fluoro-substituent is deactivated towards nucleophilic substitution by protection of a para-ketone as an acetal. This allows coupling to an activated aryl fluoride. Subsequent deprotection of the acetyl group then activates the first fluoro-substituent and allows the next generation of the dendron to be added. The synthesis of higher generations is complicated by a scrambling reaction, which lowers the yields. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.08.012