N'-(4-{4-[2-(10H-phenothiazin-2-yloxy)ethyl]-1-piperazinyl}phenyl)-2-thiophenecarboximidamide | 262447-30-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: N'-(4-{4-[2-(10H-phenothiazin-2-yloxy)ethyl]-1-piperazinyl}phenyl)-2-thiophenecarboximidamide
• 英文别名: N'-[4-[4-[2-(10H-phenothiazin-2-yloxy)ethyl]piperazin-1-yl]phenyl]thiophene-2-carboximidamide
• CAS: 262447-30-3
• 化学式: C₂₉H₂₉N₅OS₂
• 分子量: 527.714
• InChiKey: PAPJSMHTXCIPFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• New derivatives of N-(iminomethy)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
  申请人：SOCIETE DE CONSEILS DE RECHERCHES D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

  公开号：US20040097494A1

  公开（公告）日：2004-05-20

  N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.

  N-(亚胺基)胺及其制备方法，以及作为NO合酶抑制剂和对反应性氧化物的选择性或非选择性陷阱的用途。
• Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
  申请人：Bigg Dennis

  公开号：US20050197329A1

  公开（公告）日：2005-09-08

  N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.

  N-(亚硝基)胺及其制备方法和用作NO合酶抑制剂和选择性或非选择性捕捉反应性氧化物种的用途。
• New derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
  申请人：Bigg Dennis

  公开号：US20050027009A1

  公开（公告）日：2005-02-03

  N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.

  N-(亚硝基)胺及其制备方法和用途，作为NO合酶抑制剂和选择性或非选择性的反应性氧化物陷阱。
• DERIVES DE N-(IMINOMETHYL)AMINES, LEUR PREPARATIONLEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITI ONS PHARMACEUTIQUES LES CONTENANT
  申请人：SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

  公开号：EP1115720B1

  公开（公告）日：2008-07-02
• US6482822B1
  申请人：——

  公开号：US6482822B1

  公开（公告）日：2002-11-19