2-(4-methylphenyl)-3-furanoic acid | 122942-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 2-(4-methylphenyl)-3-furanoic acid
• 英文别名: 2-(4-methylphenyl)furan-3-carboxylic acid
• CAS: 122942-98-7
• 化学式: C₁₂H₁₀O₃
• 分子量: 202.21
• InChiKey: KJMZBOUAGPARQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-糠酸 、 乙烷,三氯氟- 在 盐酸 、 sodium nitrite 作用下， 生成 2-(4-methylphenyl)-3-furanoic acid
  参考文献：
  名称：

  Jurasek, Adolf; Berecinova, Daniela; Cakrt, Miroslav, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 1, p. 215 - 224

  摘要：

  DOI：

文献信息

• Triazolopyrimidine derivatives which are angiotensin II receptor
  申请人：Laboratoires Upsa

  公开号：US05387747A1

  公开（公告）日：1995-02-07

  The present invention relates to the derivatives of the formula ##STR1## and their tautomeric forms, as well as their addition salts, and to their use in therapeutics, especially for the treatment and prevention of cardiovascular diseases and in particular for the treatment of hypertension, cardiac insufficiency and diseases of the arterial wall, especially atherosclerosis.

  本发明涉及公式##STR1##的衍生物及其互变异构体形式，以及它们的加合物盐，以及它们在治疗学中的应用，特别是用于治疗和预防心血管疾病，尤其是用于治疗高血压、心力衰竭和动脉壁疾病，特别是动脉粥样硬化的治疗。
• Pyrazolopyrimidine derivatives which are angiotensin II receptor
  申请人：Laboratoires UPSA

  公开号：US05389632A1

  公开（公告）日：1995-02-14

  The present invention relates to the derivatives of the formula ##STR1## and their tautomeric forms, as well as their addition salts, and to their use in therapeutics, especially for the treatment and prevention of cardiovascular diseases and in particular for the treatment of hypertension, cardiac insufficiency and diseases of the arterial wall, especially atherosclerosis.

  本发明涉及公式##STR1##的衍生物及其互变异构体形式，以及它们的加合物盐，并且涉及它们在治疗学上的应用，特别是用于治疗和预防心血管疾病，尤其是用于治疗高血压、心力衰竭和动脉壁疾病，特别是动脉粥样硬化的治疗。
• Isoxazole derivatives as peroxisome proliferator-activated receptors agonists
  申请人：Fukui Yoshikazu

  公开号：US20070054902A1

  公开（公告）日：2007-03-08

  A compound of formula (I): (wherein R 1 -R 10 are each independently hydrogen, halogen, optionally substituted lower alkyl or the like, X 1 is —O—, —S—, —NR 11 — (wherein R 11 is hydrogen, lower alkyl or the like), —CR 12 R 13 CO—, —(CR 12 R 13 )mO—, —O(CR 12 R 13 )m- (wherein R 12 and R 13 are each independently hydrogen or lower alkyl and m is a integer between 1 and 3) or the like, X 2 is a bond, —O—, —S—, —NR 14 — (wherein R 14 is hydrogen, lower alkyl or the like, R 14 and R 6 can be taken together with the neighboring atom to form a ring) or —CR 15 R 16 — (wherein R 15 and R 16 are each independently hydrogen or lower alkyl, R 15 and R 6 or R 10 can be taken together with the neighboring carbon atom to form a ring, R 16 and R 9 can be joined together to form a bond), X 3 is COOR 17 , C(═NR 17 )NR 18 OR 19 or the like), a pharmaceutically acceptable salt or a solvate thereof.

  化合物的化学式为（I）：（其中R1-R10各自独立地为氢，卤素，可选择性取代的低碳基或类似物，X1为—O—，—S—，—NR11—（其中R11为氢，低碳基或类似物），—CR12R13CO—，—（CR12R13）mO—，—O（CR12R13）m-（其中R12和R13各自独立地为氢或低碳基，m为1到3之间的整数）或类似物，X2为键，—O—，—S—，—NR14—（其中R14为氢，低碳基或类似物，R14和R6可以与相邻的原子结合形成环）或—CR15R16—（其中R15和R16各自独立地为氢或低碳基，R15和R6或R10可以与相邻的碳原子结合形成环，R16和R9可以结合在一起形成键），X3为COOR17，C（═NR17）NR18OR19或类似物），其药学上可接受的盐或溶剂化物。
• JURASEK, ADOLF;BERECINOVA, DANIELA;CAKRT, MIROSLAV;DANDAROVA, MILOSLAVA;F+, COLLECT. CZECHOSL. CHEM. COMMUN., 54,(1989) N, C. 215-224
  作者：JURASEK, ADOLF、BERECINOVA, DANIELA、CAKRT, MIROSLAV、DANDAROVA, MILOSLAVA、F+

  DOI：——

  日期：——
• US5387747A
  申请人：——

  公开号：US5387747A

  公开（公告）日：1995-02-07