4,7-二溴-1H-吡咯并[2,3-c]吡啶 | 619331-71-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 中文名称: 4,7-二溴-1H-吡咯并[2,3-c]吡啶
• 英文名称: 4,7-dibromo-1H-pyrrolo[2,3-c]pyridine
• CAS: 619331-71-4
• 化学式: C₇H₄Br₂N₂
• 分子量: 275.93
• InChiKey: YGGJWPDZPZHYBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
  申请人：Yeung Kap-Sun

  公开号：US20050261296A1

  公开（公告）日：2005-11-24

  This invention provides compounds of Formula I, including pharmaceutically accceptable salts thereof, having drug and bio-affecting properties, their pharmaceutical compositions and method of use. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula I have the formula wherein: Z is Q is selected from the group consisting of m is 2; A is selected from the group consisting of cinnolinyl, napthyridinyl, quinoxalinyl, pyridinyl, pyrimidinyl, quinolinyl, isoquinolinyl, quinazolinyl, azabenzofuryl, and phthalazinyl each of which may be optionally substituted with one or two groups independently selected from methyl, methoxy, hydroxy, amino and halogen; and —W— is

  这项发明提供了具有药物和生物影响性质的Formula I化合物，包括其药用盐，以及它们的药物组合物和使用方法。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药物、抗感染药物、免疫调节剂或HIV进入抑制剂结合使用。更具体地，本发明涉及治疗HIV和艾滋病。Formula I化合物的结构如下：Z是Q是从以下组中选择的m为2；A是从以下组中选择的：菲啰啉基、萘啉基、喹喉基、吡啶基、嘧啶基、喹啉基、异喹啉基、喹唑啉基、氮杂苯并呋喃基和邻苯二嗪基，每种基可能被一个或两个分别选择自甲基、甲氧基、羟基、氨基和卤素的基取代；而—W—是。
• Indole, azaindole and related heterocyclic ureido and thioureido piperazine derivatives
  申请人：Regueiro-Ren Alicia

  公开号：US20060094717A1

  公开（公告）日：2006-05-04

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with ureido and thioureido piperazine derivatives of Formula I. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula I are wherein: Y is O or S; Q is selected from the group consisting of m is 2; A is NR 13 R 14 ; and —W— is

  本发明提供了具有药物和生物影响性质的化合物，它们的制药组合物和使用方法。特别地，本发明涉及式I的脲基和硫脲基哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药物、抗感染剂、免疫调节剂或HIV进入抑制剂联合使用。更具体地，本发明涉及HIV和艾滋病的治疗。式I的化合物为：其中：Y为O或S；Q选自由m为2的组；A为NR13R14；且-W-为____________。
• COMPOSITION AND ANTIVIRAL ACTIVITY OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES
  申请人：WANG TAO

  公开号：US20090306095A1

  公开（公告）日：2009-12-10

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

  本发明提供了具有药物和生物影响特性的化合物，它们的制药组合物和使用方法。特别是，本发明涉及吡嗪酮氨基甲酰基吡嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药物、抗感染药物、免疫调节剂或HIV进入抑制剂结合使用。更具体地，本发明涉及治疗HIV和艾滋病。
• PHARMACEUTICAL FORMULATIONS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES WITH PROTEASE INHIBITORS
  申请人：Wang Tao

  公开号：US20100093752A1

  公开（公告）日：2010-04-15

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

  本发明提供了具有药物和生物影响性质的化合物，它们的药物组合物和使用方法。特别是，本发明涉及氮杂吲哚氧乙酰哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药物、抗感染药物、免疫调节剂或HIV进入抑制剂结合使用。更具体地，本发明涉及治疗HIV和艾滋病。
• PRODRUGS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES
  申请人：Bristol-Myers Squibb Company

  公开号：US20150329543A1

  公开（公告）日：2015-11-19

  This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

  本发明提供具有药物和生物影响特性的化合物，其制药组合物和使用方法。特别地，本发明涉及氮杂吲哚氧乙酰基哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药物、抗感染剂、免疫调节剂或HIV进入抑制剂联合使用。更具体地，本发明涉及治疗HIV和艾滋病。