1,4,8,9-Tetraaza-2,3-dihydrotriphenylen | 29141-87-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 1,4,8,9-Tetraaza-2,3-dihydrotriphenylen
• 英文别名: 2,3-dihydro-dipyrido[3,2-f;2',3'-h]quinoxaline；2,3-Dihydropyrazino[2,3-f][1,10]phenanthroline
• CAS: 29141-87-5
• 化学式: C₁₄H₁₀N₄
• 分子量: 234.26
• InChiKey: BCHAHYXDIKKAAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  50.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,10-邻二氮杂菲-5,6-二酮 、 乙二胺 在 sulfate loaded TiO₂ 作用下， 反应 0.05h， 以96%的产率得到1,4,8,9-Tetraaza-2,3-dihydrotriphenylen
  参考文献：
  名称：

  A Recyclable Solid Acid Catalyst Sulfated Titania for Easy Synthesis of Quinoxaline and Dipyridophenazine Derivatives under Microwave Irradiation

  摘要：

  通过溶胶-凝胶法制备的TiO2–SO42−已用于在微波辐射下合成喹喔啉和二吡啶苯并嗪衍生物。高分辨率透射电子显微镜（HR-TEM）和原子力显微镜（AFM）图像揭示了硫酸对TiO2颗粒的腐蚀，从而导致催化剂酸性的增加。通过H2SO4进行的硫酸盐负载提高了TiO2的催化活性。该催化剂在较短的反应时间内提供了优异的产率，是一种价格低廉、易于回收和高效的催化剂。

  DOI：

  10.1246/bcsj.20110152

文献信息

• [EN] METAL COMPLEXES HAVING THERAPEUTIC APPLICATIONS<br/>[FR] COMPLEXES MÉTALLIQUES AYANT DES APPLICATIONS THÉRAPEUTIQUES
  申请人：ROYAL COLLEGE SURGEONS IRELAND

  公开号：WO2018015493A1

  公开（公告）日：2018-01-25

  A metal complex has the general formula (I), in which: R-Z is a HDAC inhibitor in which Z a terminal hydroxamate group; M is a redox active metal; n+ is the positive charge on the complex cation; Bn- is a balancing counterion; Z binds to M via O,O' bidendate coordination; and formula (A) is a nitrogen donor ligand selected from a bipyridine ligand or a phenanthroline ligand or phenanthroline-type ligand with the proviso that R-Z is not a dual HDAC/PARP inhibitor.

  一个金属配合物具有通式(I)，其中：R-Z是一种HDAC抑制剂，其中Z是一个末端羟羧酸酯基团；M是一个氧化还原活性金属；n+是配合物阳离子的正电荷；Bn-是平衡的对离子；Z通过O,O'双齿配位与M结合；通式(A)是从双吡啶配体或菲啰啉配体或菲啰啉型配体中选择的氮配体，但要求R-Z不是双重HDAC/PARP抑制剂。
• A recyclable and highly effective sulfated TiO2-P25 for the synthesis of quinoxaline and dipyridophenazine derivatives at room temperature
  作者：B. Krishnakumar、M. Swaminathan

  DOI：10.1016/j.jorganchem.2010.08.055

  日期：2010.11

  Sulfated TiO2-P25 has been prepared using H2SO4 and used for the synthesis of quinoxaline and dipyridophenazine derivatives. Sulfate loading by H2SO4 increases the Lewis acidity of TiO2-P25. This catalyst gives excellent yield with less reaction time and it is an inexpensive, easily recyclable catalyst for this reaction. (C) 2010 Elsevier B.V. All rights reserved.
• Solvent free synthesis of quinoxalines, dipyridophenazines and chalcones under microwave irradiation with sulfated Degussa titania as a novel solid acid catalyst
  作者：B. Krishnakumar、M. Swaminathan

  DOI：10.1016/j.molcata.2011.08.026

  日期：2011.11

  Sulfated TiO2-P25 (Degussa titania) has been prepared by sol-gel method using H2SO4 and characterized by FT-IR, XRD, FE-SEM, EDS, HR-TEM, XPS, DRS and BET surface area measurements. Sulfate loading by H2SO4 increases the Lewis acidity of Degussa tiatania. This catalyst gives an excellent yield with less reaction time and is an inexpensive and easily recyclable solid acid catalyst for the synthesis of quinaxalines, dipyridophenazines and chalcones under microwave irradiation. (C) 2011 Elsevier B.V. All rights reserved.