Methyl 1-amino-4-(2-bromophenyl)-4,5-dihydro-5-oxo-thieno[2,3-c]isoquinoline-2-carboxylate | 134672-50-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: Methyl 1-amino-4-(2-bromophenyl)-4,5-dihydro-5-oxo-thieno[2,3-c]isoquinoline-2-carboxylate
• 英文别名: Methyl 1-amino-4-(2-bromophenyl)-5-oxothieno[2,3-c]isoquinoline-2-carboxylate
• CAS: 134672-50-7
• 化学式: C₁₉H₁₃BrN₂O₃S
• 分子量: 429.294
• InChiKey: CHYAHRVJOKUKLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Novel compounds exhibiting a vasodilating activity and inhibitory activity for platelet aggregation and pharmaceutical compositions containing them
  申请人：Hidaka, Hiroyoshi

  公开号：EP0416820A2

  公开（公告）日：1991-03-13

  Novel compounds represented by the formula: wherein R₁ represents an alkyl group having 1 to 3 carbon atoms, R₂ represents an amino group or a group of formula in which R₄ represents an alkyl group having 1 to 3 carbon atoms, R₅ represents an alkyl group having 1 to 3 carbon atoms or may combine with R₆ to form a five or six membered ring containing 4 to 5 carbon atoms, R₆ represents a hydrogen atom or may combine with R₅ to form a five or six membered ring containing 4 to 5 carbon atoms, R₃ represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a halogen atom, X represents a carbonyl group or a methylene group, Y represents a sulfur atom or a vinylene group and pharmaceutically acceptable salts thereof which exhibit a vasodilating activity and inhibitory activity for platelet aggregation. Thus, they are useful as therapeutic agents for treat­ment of angina pectoris, hypertension, thrombosis and the like.

  由以下式子表示的新型化合物 其中 R₁ 代表具有 1 至 3 个碳原子的烷基，R₂ 代表氨基或式中的基团 其中 R₄ 代表具有 1 至 3 个碳原子的烷基，R₅ 代表具有 1 至 3 个碳原子的烷基或可与 R₆ 结合形成含有 4 至 5 个碳原子的五或六元环，R₆ 代表氢原子或可与 R₅ 结合形成含有 4 至 5 个碳原子的五或六元环、R₃代表氢原子、具有 1 至 3 个碳原子的烷基或卤素原子，X 代表羰基或亚甲基，Y 代表硫原子或乙烯基及其药学上可接受的盐，它们具有血管扩张活性和血小板聚集抑制活性。 因此，它们可用作治疗心绞痛、高血压、血栓形成等疾病的治疗剂。
• US5059692A
  申请人：——

  公开号：US5059692A

  公开（公告）日：1991-10-22