5-Carbamoyl-thionaphthen | 1199-25-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 5-Carbamoyl-thionaphthen
• 英文别名: benzo[b]thiophene-5-carboxylic acid amide；1-Benzothiophene-5-carboxamide
• CAS: 1199-25-3
• 化学式: C₉H₇NOS
• mdl: MFCD20707631
• 分子量: 177.227
• InChiKey: SWLXXUVUBCIWHL-UHFFFAOYSA-N

物化性质

• 熔点：
  175-177 °C
• 沸点：
  411.5±18.0 °C(Predicted)
• 密度：
  1.345±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY<br/>[FR] ACIDES HYDROXAMIQUES BICYCLIQUES UTILES COMME INHIBITEURS DE L'ACTIVITÉ HISTONE DÉSACÉTYLASE CHEZ LE MAMMIFÈRE
  申请人：KANCERA AB

  公开号：WO2017108282A1

  公开（公告）日：2017-06-29

  A compound of formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of a histone deacetylase, and as such is useful in terepy, e.g. in the treatment of autoimmune disorders, mental disorders, neurodegenerative disorders, and hyperproliferative disorders.

  化合物的化学式（Ia）或（Ib）或其药学上可接受的盐。该化合物是组蛋白去乙酰化酶的抑制剂，因此在治疗自身免疫性疾病、精神障碍、神经退行性疾病和过度增生性疾病等方面非常有用。
• [EN] SUBSTITUTED 4-PYRIDONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY<br/>[FR] 4-PYRIDONES SUBSTITUÉES ET LEUR UTILISATION COMME INHIBITEURS DE L'ACTIVITÉ DE L'ÉLASTASE NEUTROPHILE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2014029832A1

  公开（公告）日：2014-02-27

  P01-2864-ff 32/132 -132- ABSTRACT This invention relates to substituted 4-pyridones of formula R 1a R 7 R 6 R R 3 N O O N H R 4 R 2 R 1b A 1 and their use as inhibitors ofneutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases.

  这项发明涉及化学式为R 1a R 7 R 6 R R 3 N O O N H R 4 R 2 R 1b A 1的取代4-吡啶酮，以及它们作为中性粒细胞弹性蛋白酶活性抑制剂的用途，含有相同化合物的制药组合物，以及将其用作治疗和/或预防肺部、胃肠道和泌尿系统疾病、皮肤和眼睛的炎症性疾病、其他自身免疫和过敏性疾病、移植物排斥反应和肿瘤性疾病的药剂的方法。
• Imidazole compounds
  申请人：——

  公开号：US20020058659A1

  公开（公告）日：2002-05-16

  A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

  一种新型的咪唑杂环化合物类，包括它们的药物组合物以及在治疗和/或预防与组织胺H3受体相关的疾病和疾病的用途。更具体地说，这些化合物对于治疗和/或预防与组织胺H3受体相互作用有益的疾病和疾病是有用的。
• Composition containing carbon nanotubes having coating thereof and process for producing them
  申请人：Saitoh Takashi

  公开号：US20060052509A1

  公开（公告）日：2006-03-09

  The object of the present invention is to provide a carbon nanotube composition that does not impair the characteristics of the carbon nanotubes itself, allows the carbon nanotubes to be dispersed or solubilized in a solvent, does not cause separation or aggregation of the carbon nanotubes even during long-term storage, has superior electrical conductivity, film formability and moldability, can be easily coated or covered onto a base material, and the resulting coated film has superior moisture resistance, weather resistance and hardness; a composite having a coated film composed thereof; and, their production methods. In order to achieve this object, the present invention provides a carbon nanotube composition that contains a conducting polymer (a) or heterocyclic compound trimer (i), a solvent (b) and carbon nanotubes (c), and may additionally contain a high molecular weight compound (d), a basic compound (e), a surfactant (f), a silane coupling agent (g) and colloidal silica (h) as necessary; a composite having a coated film composed of the composition; and, their production methods.

  本发明的目的是提供一种碳纳米管组合物，不会影响碳纳米管本身的特性，使碳纳米管可以分散或溶解在溶剂中，在长期储存期间不会导致碳纳米管分离或聚集，具有优异的电导性、成膜性和成型性，可以轻松地涂覆或覆盖在基材上，所得到的涂层膜具有优异的防潮性、耐候性和硬度；一种由涂层膜组成的复合材料；以及它们的生产方法。为了实现这一目的，本发明提供了一种碳纳米管组合物，其中包含导电聚合物(a)或杂环化合物三聚体(i)、溶剂(b)和碳纳米管(c)，并可根据需要另外包含高分子量化合物(d)、碱性化合物(e)、表面活性剂(f)、硅烷偶联剂(g)和胶体二氧化硅(h)；一种由该组合物组成的涂层膜复合材料；以及它们的生产方法。
• N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
  申请人：John Varghese

  公开号：US20070213316A1

  公开（公告）日：2007-09-13

  Disclosed are compounds of the formula wherein the variables R N , R C , R 1 , R 25 , R 2 , and R 3 are as defined herein. These compounds have activity as inhibitors of beta-secretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.

  本发明揭示了以下式子的化合物：其中变量RN，RC，R1，R25，R2和R3如本文所定义。这些化合物具有抑制β-分泌酶的活性，因此可用于治疗多种疾病，例如阿尔茨海默病。