2-[[2-({2-[2-(acetylamino)-1,3-thiazol-4-yl]acetyl}amino)-1,3-thiazol-5-yl](methyl)amino]ethyl acetate | 1082344-38-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[[2-({2-[2-(acetylamino)-1,3-thiazol-4-yl]acetyl}amino)-1,3-thiazol-5-yl](methyl)amino]ethyl acetate
• 英文别名: 2-[[2-[[2-(2-Acetamido-1,3-thiazol-4-yl)acetyl]amino]-1,3-thiazol-5-yl]-methylamino]ethyl acetate
• CAS: 1082344-38-4
• 化学式: C₁₅H₁₉N₅O₄S₂
• 分子量: 397.479
• InChiKey: WGEOCNZIEILGBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  170
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Arylmethyl-carbonylamino-thiazole derivatives and their use as antitumor agents
  申请人：Pevarello Paolo

  公开号：US20050004120A1

  公开（公告）日：2005-01-06

  A method of modulating apoptosis or treating diseases associated with protein kinases by administering to a mammal in need thereof of an effective amount of 2-amino-1,3-thiazole derivatives represented by formula (I) or (II): where R, R 1 , R 2 and R 3 are as defined herein, or pharmaceutically acceptable salts thereof.

  通过向需要的哺乳动物投予有效量的由公式(I)或(II)表示的2-氨基-1,3-噻唑衍生物，或其药学上可接受的盐，来调节凋亡或治疗与蛋白激酶相关的疾病的方法：其中R、R1、R2和R3如本文所定义。
• ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1204649A1

  公开（公告）日：2002-05-15
• US6114365A
  申请人：——

  公开号：US6114365A

  公开（公告）日：2000-09-05
• US6784198B1
  申请人：——

  公开号：US6784198B1

  公开（公告）日：2004-08-31
• [EN] ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS<br/>[FR] DERIVES D'ARYLMETHYL-CARBONYLAMINO-THIAZOLE UTILISATION DE CEUX-CI COMME AGENTS ANTITUMORAUX
  申请人：PHARMACIA & UPJOHN SPA

  公开号：WO2001014353A1

  公开（公告）日：2001-03-01

  2-amino-1,3-thiazole derivatives represented by formula (I) or (II): where R, R1, R2 and R3 are as defined herein, or pharmaceutically acceptable salts thereof, are useful in, for example, the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenertive diseases.