3-butyl-5,7-dichloro-1H-quinazoline-2,4-dione | 1000860-00-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-butyl-5,7-dichloro-1H-quinazoline-2,4-dione
• CAS: 1000860-00-3
• 化学式: C₁₂H₁₂Cl₂N₂O₂
• 分子量: 287.145
• InChiKey: TXHMVDWTZARNMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL SUBSTITUTED-1-H-QUINAZOLINE-2,4-DIONE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Seong Churlmin

  公开号：US20090203708A1

  公开（公告）日：2009-08-13

  Disclosed herein are novel substituted-1H-quinazoline-2,4-dione derivatives, a preparation method thereof, and a pharmaceutical composition containing the same. The novel substituted-1H-quinazoline-2,4-dione derivatives are excellent in binding affinity and selectivity for 5-HT6 receptors over other receptors, inhibit serotonin(5-HT)-stimulated cAMP accumulation, and disrupt apomorphine(2 mg/kg, i.p.)-induced hyperactivity in rats. Thanks to these effects, the derivatives are useful in the treatment of 5-HT6 receptor-related central nervous system diseases.

  本文披露了一种新型的取代-1H-喹唑啉-2,4-二酮衍生物，其制备方法以及含有该衍生物的药物组合物。这种新型的取代-1H-喹唑啉-2,4-二酮衍生物在与其他受体相比对5-HT6受体的结合亲和力和选择性方面表现出色，抑制5-羟色胺（5-HT）刺激的cAMP积累，并破坏大鼠中阿波莫啡（2 mg/kg，i.p.）诱导的过度活动。由于这些效果，这些衍生物在治疗与5-HT6受体相关的中枢神经系统疾病中非常有用。
• Insecticidal Substituted Aminoalkyl Heterocyclic and Heteroaryl Derivatives
  申请人：Dixson John A.

  公开号：US20090209422A1

  公开（公告）日：2009-08-20

  Certain substituted aminoalkyl heteroaryl and heterocyclyl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein R, R 1 , R 2 , R 3 and R 4 are folly described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of an additional compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  某些取代氨基烷基杂芳基和杂环基衍生物提供了意外的杀虫和杀螨活性。这些化合物由公式I表示：其中R，R1，R2，R3和R4在此完整描述。此外，还公开了包含公式I中至少一种化合物的杀虫有效量和可选地至少一种其他化合物的有效量，以及至少一种杀虫兼容载体的组合物；以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的地点。
• INSECTICIDAL SUBSTITUTED AMINOALKYL HETEROCYCLIC AND HETEROARYL DERIVATIVES
  申请人：Bayer CropScience AG

  公开号：EP1879455A1

  公开（公告）日：2008-01-23
• NOVEL SUBSTITUTED-1H-QUINAZOLINE-2,4-DIONE DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP2035406A1

  公开（公告）日：2009-03-18
• EP2035406A4
  申请人：——

  公开号：EP2035406A4

  公开（公告）日：2009-08-05