N-cyano-N’,N’-dipropylguanidine | 13348-83-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-cyano-N’,N’-dipropylguanidine
• 英文别名: 2-Cyano-1,1-dipropylguanidine
• CAS: 13348-83-9
• 化学式: C₈H₁₆N₄
• 分子量: 168.242
• InChiKey: RHBSRXDPAMHQIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  65.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Polyether bisbiguanides
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0125827A1

  公开（公告）日：1984-11-21

  This invention relates to a polyether bisbiguanide derivative of the formula:- or a tautomerthereof, wherein R', R2, R5 and R8, which may be the same or different, are each hydrogen, a 1-16C alkyl radical, a 2-16C alkoxyalkyl radical a 3-12C cycloalkyl radical, a (3-12C cycloalkyl)-(1-4C alkyl) radical, an optionally substituted phenyl, phenyl (1-4C alkyl) or phenyl (1-4C alkoxy) 1-4C alkyl) radical, or R' and R2 and the nitrogen atom to which they are attached, or R5 and R6 and the nitrogen atom to which they are attached, which may be the same or different, are each a I-azetidinyl, 1-pyrrolidinyl, piperidino, hexamethyleneimino, heptamethyleneimino, morpholino or 4-(1-8C alkanoyl)-1-piperazinyl radical; each of which may bear 1-3C alkyl sub- stituents; R3 and R4, which may be the same or different, are each hydrogen or 1-16C alkyl radical, a 3-16C cycloalkyl radical, a (3-12C cyclo-alkyl)-(1-4C alkyl) radical, an optionally substituted phenyl radical, an optionally substituted phenyl (1-4C alkyl) or naphthyl (1-4C alkyl) radical, or an optionally substituted diphenylmethyl radical; R7 and R8 are each hydrogen or a 1-8C alkyl radical; and X is a linking group of the formula:- wherein Z' and Z2 are each an oxygen or sulphur atom, Y is a polymethylene, p-phenylene, 1,4-phenylene-dimethylene or 1,5-naphthylene radical, a radical of the formula:- or a polymethylene radical which is interrupted by up to 5 ether oxygen or thioether sulphur atoms, and x and y are integers being 2 or greater, such that the total number of methylene groups in the linking group X is not more than 18; and the acid-addition salts thereof; to processes for their manufacture; and to compositions and methods of use thereof.

  本发明涉及一种式如下的聚醚双胍衍生物 或其同系物，其中R'、R2、R5和R8可以相同或不同，各自为氢、1-16C烷基、2-16C烷氧基烷基、3-12C环烷基、(3-12C环烷基)-(1-4C烷基)基、任选取代的苯基、苯基(1-4C烷基)或苯基(1-4C烷氧基)1-4C烷基、或 R'和 R2 及其连接的氮原子，或 R5 和 R6 及其连接的氮原子（可以相同或不同）各自为 I-氮杂环丁基、1-吡咯烷基、哌啶基、六亚甲基亚氨基、七亚甲基亚氨基、吗啉基或 4-(1-8C烷酰基)-1-哌嗪基；R3 和 R4 可以相同或不同，各自为氢或 1-16C 烷基、3-16C 环烷基、(3-12C 环烷基)-(1-4C 烷基)基、任选取代的苯基、任选取代的苯基 (1-4C 烷基) 或萘基 (1-4C 烷基) 或任选取代的二苯基甲基；R7 和 R8 分别是氢或 1-8C 烷基；以及 X 是式中的连接基团：- 其中 Z'和 Z2 各为氧原子或硫原子，Y 为聚亚甲基、对亚苯基、1,4-亚苯基二甲基或 1,5-萘基，式中的一个基团：- 或被最多 5 个醚氧原子或硫醚硫原子打断的聚亚甲基基，且 x 和 y 为 2 或更大的整数，使得连接基团 X 中亚甲基的总数不超过 18 个；及其酸加成盐；其制造工艺；以及其组合物和使用方法。
• Biguanide compound and use thereof
  申请人：ImmunoMet Therapeutics Inc.

  公开号：US10626085B2

  公开（公告）日：2020-04-21

  The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.

  本发明涉及一种胍类化合物及其用途，更具体地说，涉及一种在抑制癌细胞增殖、癌症转移和癌症复发方面具有卓越效果的胍类衍生物；其制备方法；以及一种以其为有效成分的药物组合物。与现有药物相比，根据本发明的胍类衍生物即使剂量很小，也能显示出极佳的抑制癌细胞增殖、癌转移和癌症复发的效果，因此可有效用于预防或治疗各种癌症，如子宫癌、乳腺癌、胃癌、脑癌、直肠癌、大肠癌、肺癌、皮肤癌、血癌、肝癌等，抑制癌细胞增殖和癌转移。
• BIGUANIDE COMPOUND AND USE THEREOF
  申请人：Immunomet Therapeutics Inc.

  公开号：EP3222614B1

  公开（公告）日：2020-07-29
• DUAL INHIBITOR COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS AND ALZHEIMER'S DISEASE
  申请人：Fondazione Istituto Italiano di Tecnologia

  公开号：EP3154953B1

  公开（公告）日：2018-04-04
• Dual Inhibitor Compounds for Use in the Treatment of Neurodegenerative Disorders and Alzheimer's Disease
  申请人：FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

  公开号：US20170096406A1

  公开（公告）日：2017-04-06

  The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.