(2-Hydroxy-naphthyl-(1))-(1-mercapto-naphthyl-(2))-aether | 408341-50-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2-Hydroxy-naphthyl-(1))-(1-mercapto-naphthyl-(2))-aether
• 英文别名: 2-(2-Hydroxy-naphthyl-(1)-oxy)-naphthyl-(1)-mercaptan；2-(2-Hydroxy-naphthyl-(1)-oxy)-naphthalinthiol-(1)；1-(1-Mercapto-[2]naphthyloxy)-[2]naphthol；2-Oxy-1'-mercapto-(1.2'-dinaphthylaether)
• CAS: 408341-50-4
• 化学式: C₂₀H₁₄O₂S
• 分子量: 318.396
• InChiKey: KKVOYGQBPUGDOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.78
• 重原子数：
  23.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.46
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (2-Hydroxy-naphthyl-(1))-(1-mercapto-naphthyl-(2))-aether 在 camphor-10-sulfonic acid 、 氨 作用下， 生成 1,1'-硫联二(2-萘酚)
  参考文献：
  名称：

  Human Papillomavirus and Risk of Laryngeal Cancer

  摘要：

  我们确定了人乳头瘤病毒（HPV）感染与44名鳞状细胞癌患者、10名喉白斑患者和12名良性喉部疾病患者（对照组）检测到的HPV类型之间的关系。HPV DNA的来源包括来自上呼吸道和病变（良性或恶性）的刷拭、口腔漱洗和患者病变的活检。使用聚合酶链反应（PCR）和DNA测序来鉴定和分类HPV。我们在44名喉癌患者中检测到25.0%（11/44）的HPV，在10名喉白斑患者中检测到30.0%（3/10）的HPV，在非癌症对照组中检测到16.7%（2/12）的HPV。癌症患者更有可能被识别为致癌性HPV类型（18.2%）而不是白斑组（20%）或对照组（16.7%）。与对照组相比，癌症患者与白斑患者与疾病风险增加相关联，与目前吸烟和过去饮酒有关（所有p < .05）。在控制烟草和酒精对疾病风险的影响后，暴露于致癌性HPV类型与增加患喉癌（比值比=3.0）和患喉白斑（比值比=6.0）的风险相关联，尽管结果在统计学上不显著。该研究表明，尽管与对照组相比，在喉癌或喉白斑中HPV感染和HPV致癌类型的频率并不更高，但在控制酒精和烟草使用的影响后，感染与疾病风险增加相关联。

  DOI：

  10.1177/000348940010901114
• 作为产物：
  描述：

  (2-hydroxy-[1]naphthyl)-(2-oxo-2H-[1]naphthylidene)-sulfonium-betaine 在 溶剂黄146 、 锌 作用下， 生成 (2-Hydroxy-naphthyl-(1))-(1-mercapto-naphthyl-(2))-aether
  参考文献：
  名称：

  Lesser; Gad, Chemische Berichte, 1923, vol. 56, p. 968

  摘要：

  DOI：

文献信息

• CXXXII.—The conversion of iso-β-naphthol sulphide into 2-naphthol l-sulphide
  作者：Leonard Arthur Warren、Samuel Smiles

  DOI：10.1039/jr9310000914

  日期：——
• Effect of Moisture Content on the Thermomechanical Behavior of Concentrated Waxy Cornstarch–Water Preparations— A Comparison with Wheat Starch
  作者：A. Rolee、E. Chiotelli、M. Le Meste

  DOI：10.1111/j.1365-2621.2002.tb09451.x

  日期：2002.4

  ABSTRACT: The rheological behavior of waxy cornstarch preparations at intermediate moisture contents (30 to 60% w/w) was studied by dynamic mechanical thermal analysis (DMTA). Differential scanning calorimetry (DSC) and electron spin resonance (ESR) experiments were also performed in parallel. The results were compared to those obtained previously for wheat starch. DMTA results evidenced a critical moisture content (between 50 and 55%) for waxy cornstarch that delimited a radical change in the rheological behavior both at room temperature and during heating. This critical water content was around 45% for wheat starch.
• Hinsberg, Journal fur praktische Chemie (Leipzig 1954), 1915, vol. <2> 91, p. 320
  作者：Hinsberg

  DOI：——

  日期：——
• Hinsberg, Journal fur praktische Chemie (Leipzig 1954), 1914, vol. <2> 90, p. 349
  作者：Hinsberg

  DOI：——

  日期：——
• Cytokine-Driven Inflammatory Response Is Associated with the Hypermetabolism of AIDS Patients with Opportunistic Infections
  作者：Pilar Garcia-Lorda、Pilar Serrano、María Jesús Jiménez-Expósito、Julia Fraile、Mónica Bulló、Carlos Alonso、Anna Bonada、Pompeyo Viciana、Pedro P. García Luna、Jordi Salas-Salvadó

  DOI：10.1177/0148607100024006317

  日期：2000.11

  Background: To assess a possible role of systemic inflammation in the resting metabolic response in AIDS patients with active secondary infections. Methods: Fifty‐two patients with AIDS‐defined criteria and concomitant active infections and 19 healthy subjects were studied. Measurements were as follows: body composition assessed by bioelectrical impedance; resting energy expenditure (REE) by 30‐minute indirect calorimetry; cytokine concentrations (IL‐6, IFNα, TNFα, sTNF‐R1) by ELISA; C‐reactive protein (CRP), erythrocyte sedimentation rate, fibrinogen, and nutritional parameters by standard techniques. Results: REE adjusted for fat‐free mass (REEFFM) was significantly increased in AIDS patients despite 39% of them not being hypermetabolic. The patients were undernourished and were found to have increased levels of acute‐phase proteins and increased concentrations of IL‐6 and sTNF‐R1 relative to controls. REE parameters were positively related to CRP, ESR, ferritin, IL‐6, and sTNF‐R1 and negatively related to albumin, prealbumin, and transferrin. CRP was an independent predictor of REEFFM in AIDS patients and explained 25% of its variability. Patients with severe inflammation (CRP ≥ 37 mg/dL) were significantly hypermetabolic with respect to patients without inflammation (CRP < 6 mg/dL) and had higher levels of IL‐6 and sTNF‐R1 and lower levels of albumin and prealbumin. Although no significant differences were observed with respect to the infection type, patients with tuberculosis and Pneumocystis carinii infections had higher resting metabolic and inflammatory responses, whereas patients with recurrent bacterial pneumonia were normometabolic and had lower levels of inflammatory markers. Conclusions: Resting hypermetabolism observed in AIDS patients with concurrent active infections is related to the presence and severity of systemic cytokine‐driven inflammatory response, which could reflect the type of secondary infection. (Journal of Parenteral and Enteral Nutrition 24:317–322, 2000)