(1R,3S)-3-methoxy-N-methylcyclopentan-1-amine | 1268521-86-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1R,3S)-3-methoxy-N-methylcyclopentan-1-amine
• CAS: 1268521-86-3
• 化学式: C₇H₁₅NO
• 分子量: 129.2
• InChiKey: HAPFZBJQSMUMBG-RQJHMYQMSA-N

物化性质

• 沸点：
  165.2±33.0 °C(Predicted)
• 密度：
  0.91±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] METHODS FOR THE TREATMENT OF FIBROTIC DISEASE<br/>[FR] MÉTHODES POUR LE TRAITEMENT D'UNE MALADIE FIBROTIQUE
  申请人：SHY THERAPEUTICS LLC

  公开号：WO2022164997A1

  公开（公告）日：2022-08-04

  Provided herein are methods and corresponding compounds for treating fibrotic disease by administering to a subject a compound of Formula I or pharmaceutically acceptable salt thereof, which inhibits phosphorylation of Smad2/3, according to Phospho-Smad2/3 Inhibition Assay, including compounds that are active according to MAPK p38 Activation Assay; or a compound of Formula II or III. Also provided are methods and corresponding compounds for treating cancers, inflammatory diseases, rasopathies and autoimmune leukoproliferative disorders.

  本文提供了一种通过给予一种I式化合物或其药学上可接受的盐治疗纤维化疾病的方法和相应的化合物，该化合物抑制Smad2 / 3的磷酸化，根据Phospho-Smad2 / 3 Inhibition Assay，其中包括根据MAPK p38 Activation Assay活性的化合物；或一种II或III式化合物。还提供了一种通过给予相应的化合物治疗癌症，炎症性疾病，rasopathies和自身免疫性白血病增生性疾病的方法和相应的化合物。
• [EN] SUBSTITUTED THIENOPYRIMIDINES THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE<br/>[FR] THIÉNOPYRIMIDINES QUI INTERAGISSENT AVEC LA SUPERFAMILLE RAS POUR LE TRAITEMENT DE CANCERS, DE MALADIES INFLAMMATOIRES, DE RASOPATHIES ET D'UNE MALADIE FIBREUSE
  申请人：[en]SHY THERAPEUTICS, LLC

  公开号：WO2021257828A1

  公开（公告）日：2021-12-23

  Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a method for assaying such compositions.