CP 465022 Hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: CP 465022 Hydrochloride
• 英文别名: 3-(2-chlorophenyl)-2-[(E)-2-[6-(diethylaminomethyl)pyridin-2-yl]ethenyl]-6-fluoroquinazolin-4-one;hydrochloride
• 化学式: C26H25Cl2FN4O
• 分子量: 499.4
• InChiKey: YKYDGCRJPYLXHY-GVYCEHEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.01
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  48.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Methods and compositions for the treatment of alzheimer
  申请人：Universidad del Pais Vasco

  公开号：EP2338492A1

  公开（公告）日：2011-06-29

  The invention relates to AMPA receptor inhibitors and NMDA receptor inhibitors for use in the treatment of a disease associated with deposition of amyloid proteins, more precisely, Alzheimer.

  本发明涉及 AMPA 受体抑制剂和 NMDA 受体抑制剂，用于治疗与淀粉样蛋白沉积有关的疾病，更确切地说，是阿尔茨海默病。
• MITIGATION OF CNS DISORDERS BY COMBINATION THERAPY USING NEUROSTEROIDS, AND AMPA BLOCKERS
  申请人：The Regents of the University of California

  公开号：US20200030304A1

  公开（公告）日：2020-01-30

  Provided are compositions and methods for treating epilepsy, including epilepsy caused by exposure to organophosphate nerve agents, that entail co-formulation and/or co-administration of a benzodiazepine, a neurosteroid and an AMPA receptor antagonist.
• [EN] MITIGATION OF CNS DISORDERS BY COMBINATION THERAPY USING NEUROSTEROIDS, AND AMPA BLOCKERS<br/>[FR] ATTÉNUATION DE TROUBLES DU SNC PAR POLYTHÉRAPIE FAISANT INTERVENIR DES NEUROSTÉROÏDES, ET DES BLOQUEURS AMPA
  申请人：UNIV CALIFORNIA

  公开号：WO2018169798A1

  公开（公告）日：2018-09-20

  Provided are compositions and methods for treating epilepsy, including epilepsy caused by exposure to organophosphate nerve agents, that entail co-formulation and/or co-administration of a benzodiazepine, a neurosteroid and an AMPA receptor antagonist.