2α,3α-dihydroxy-6-oxo-5α-androstan-17β-yl (2R,3R)-azido-3-methylpentanoate | 1251071-19-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2α,3α-dihydroxy-6-oxo-5α-androstan-17β-yl (2R,3R)-azido-3-methylpentanoate
• 英文别名: [(2R,3S,5S,8R,9S,10R,13S,14S,17S)-2,3-dihydroxy-10,13-dimethyl-6-oxo-1,2,3,4,5,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl] (2R,3R)-2-azido-3-methylpentanoate
• CAS: 1251071-19-8
• 化学式: C₂₅H₃₉N₃O₅
• 分子量: 461.602
• InChiKey: DEVVRHPROMRGIO-GIORMPJTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  98.2
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  6-oxo-2α,3α-(2,2-propylendioxy)-5α-androstan-17β-yl (2R,3R)-azido-3-methylpentanoate 在 盐酸 、 水 作用下， 以 氯仿 为溶剂， 反应 0.02h， 以33%的产率得到2α,3α-dihydroxy-6-oxo-5α-androstan-17β-yl (2R,3R)-azido-3-methylpentanoate
  参考文献：
  名称：

  The synthesis of androstane brassinosteroid analogues with α-azido acid ester groups in position 17β

  摘要：

  Androstane brassinosteroid analogues with cc-azido acid ester groups in position 17 beta were synthesized from 2 alpha,3 alpha,17 beta-trihydroxy-5 alpha-androstan-6-one after the protection of the 2 alpha,3 alpha-diols upon treatment with the corresponding cc-azido acid and the subsequent deprotection of the diol grouping. Six new castasterone analogues were prepared. The biological activities were evaluated in two bioassays: a rice lamina inclination test and bean second internode bioassays. The activities of the new analogues differ in these two bioassays. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.steroids.2010.06.012