4-Hydroxy-3,4-dihydro-chinazolin | 205926-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-Hydroxy-3,4-dihydro-chinazolin
• 英文别名: 1,4-Dihydro-4-quinazolinol；1,4-dihydroquinazolin-4-ol
• CAS: 205926-62-1
• 化学式: C₈H₈N₂O
• 分子量: 148.164
• InChiKey: RFXUVQZRJWPTLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  44.6
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] QUINAZOLIN-4(3H)-ONE-TYPE PIPERIDINE COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS DE PIPÉRIDINE DU TYPE QUINAZOLIN-4(3H)-ONE ET UTILISATIONS DE CEUX-CI
  申请人：PURDUE PHARMA LP

  公开号：WO2014102589A1

  公开（公告）日：2014-07-03

  The present disclosure relates to Quinazolin-4(3H)-one-Type Piperidine Compounds, such as those of Formule (I) and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, Q, Y1, Z, A, B, E, and a are as defined herein; compositions comprising an effective amount of a Quinazolin-4(3H)-one-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Quinazolin-4(3 H)-one-Type Piperidine Compound.

  本公开涉及喹唑啉-4(3H)-酮型哌啶化合物，例如公式(I)中的化合物及其药学上可接受的盐和溶剂，其中R1、R2、R3、Q、Y1、Z、A、B、E和a如本文所定义；包含有效量喹唑啉-4(3H)-酮型哌啶化合物的组合物；以及治疗或预防疼痛等疾病的方法，包括向需要的动物施用有效量喹唑啉-4(3H)-酮型哌啶化合物。
• [EN] INTESTINAL ALKALINE PHOSPHATASE MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE LA PHOSPHATASE ALCALINE INTESTINALE ET LEURS UTILISATIONS
  申请人：BURNHAM INST MEDICAL RESEARCH

  公开号：WO2009143150A2

  公开（公告）日：2009-11-26

  Disclosed are modulators, i.e., activators and inhibitors, of Intestinal Alkaline Phosphatase (IAP). Also disclosed are methods for treating bacterial infections of the intestinal tract and methods for maintaining the health of the intestinal tract using IAP activators. Further disclosed are methods to assist in weight gain of emaciated patients and those having reduced or negligible fat absorption using IAP inhibitors.