7-(benzo[d]oxazol-2-ylamino)-9-methyl-N-(1,3,4-thiadiazol-2-yl)-6,8-diazaspiro[4.5]deca-6,9-diene-10-carboxamide | 1428529-96-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 7-(benzo[d]oxazol-2-ylamino)-9-methyl-N-(1,3,4-thiadiazol-2-yl)-6,8-diazaspiro[4.5]deca-6,9-diene-10-carboxamide
• 英文别名: 7-(1,3-benzoxazol-2-ylamino)-9-methyl-N-(1,3,4-thiadiazol-2-yl)-6,8-diazaspiro[4.5]deca-6,9-diene-10-carboxamide
• CAS: 1428529-96-7
• 化学式: C₁₉H₁₉N₇O₂S
• 分子量: 409.472
• InChiKey: RXJOSQCTBQHIIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  146
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] GALACTOKINASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF ASSOCIATED DISEASES AND DISORDERS<br/>[FR] INHIBITEURS DE GALACTOKINASE POUR LE TRAITEMENT ET LA PRÉVENTION DE MALADIES ET DE TROUBLES ASSOCIÉS
  申请人：US HEALTH

  公开号：WO2013043192A1

  公开（公告）日：2013-03-28

  Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. Formula (I)

  本发明涉及一种公开的人类半乳糖激酶抑制剂，其化学式为（1），可用于治疗或预防半乳糖激酶介导的疾病或疾病，例如半乳糖血症。还公开了一种包含药学上可接受的载体和本发明中至少一种抑制剂的组合物，以及一种在哺乳动物中治疗或预防该类疾病或疾病的方法。化学式（I）
• Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：US10471061B2

  公开（公告）日：2019-11-12

  Disclosed are inhibitors of human galactokinase of formula (I) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. Formula (I).

  本发明公开了式(I)的人半乳糖激酶抑制剂，可用于治疗或预防半乳糖激酶介导的疾病或紊乱，如半乳糖血症。还公开了一种包含药学上可接受的载体和至少一种本发明抑制剂的组合物，以及一种治疗或预防哺乳动物中此类疾病或紊乱的方法。式 (I).
• GALACTOKINASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF ASSOCIATED DISEASES AND DISORDERS
  申请人：Boxer Matthew B.

  公开号：US20140288100A1

  公开（公告）日：2014-09-25

  Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. Formula (I)
• US9447087B2
  申请人：——

  公开号：US9447087B2

  公开（公告）日：2016-09-20
• [EN] GALACTOKINASE INHIBITORS<br/>[FR] INHIBITEURS DE GALACTOKINASE
  申请人：UNIV UTAH RES FOUND

  公开号：WO2021216812A1

  公开（公告）日：2021-10-28

  Described herein are compounds that inhibit galactokinase (GALK) and other kinases and methods for producing the same. Also described are methods for using Structure-Activity Relationships (SAR) to develop compounds with enhanced activity.