N-[(3S)-1-(1,1-dioxo-(3H,4H,5H-benzo[f]-1,2,5-thiadiazepin-2-yl))-5-methyl-2-oxo-3-hexyl]-(1R,2S)-2-benzoylaminocyclo hexylcarboxamide | 352356-28-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-[(3S)-1-(1,1-dioxo-(3H,4H,5H-benzo[f]-1,2,5-thiadiazepin-2-yl))-5-methyl-2-oxo-3-hexyl]-(1R,2S)-2-benzoylaminocyclo hexylcarboxamide
• 英文别名: N-[(1S,2R)-2-[[(3S)-1-(1,1-dioxo-4,5-dihydro-3H-1lambda6,2,5-benzothiadiazepin-2-yl)-5-methyl-2-oxohexan-3-yl]carbamoyl]cyclohexyl]benzamide；N-[(1S,2R)-2-[[(3S)-1-(1,1-dioxo-4,5-dihydro-3H-1λ6,2,5-benzothiadiazepin-2-yl)-5-methyl-2-oxohexan-3-yl]carbamoyl]cyclohexyl]benzamide
• CAS: 352356-28-6
• 化学式: C₂₉H₃₈N₄O₅S
• 分子量: 554.711
• InChiKey: VRBLTFPFTZFOQR-CUYJMHBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  133
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Benzene-fused heterocycle derivatives and drugs containing the same as the active ingredient
  申请人：——

  公开号：US20030162964A1

  公开（公告）日：2003-08-28

  A benzene-fused heteroring derivative of formula (I) 1 , wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of immune diseases (autoimmune diseases, infectious diseases, etc.), inflammatory diseases (inflammatory bowel diseases, multiple cerebrosclerosis, arthritis, etc.), nerve degeneration diseases (Alzheimer's disease, muscular dystrophy, etc.), bone resorption diseases (osteoporosis, etc.), respiratory system diseases, diabetes, shock, etc.

  式(I)1的苯融合杂环衍生物，其中所有符号与说明书中描述的相同，并其非毒性盐。式(I)的化合物对半胱氨酸蛋白酶具有抑制活性，因此可用作预防和/或治疗免疫疾病（自身免疫疾病、传染病等）、炎症性疾病（炎症性肠病、多发性硬化、关节炎等）、神经退行性疾病（阿尔茨海默病、肌营养不良等）、骨吸收疾病（骨质疏松症等）、呼吸系统疾病、糖尿病、休克等。
• Benzene-fused heteroring derivatives and pharmaceutical agents comprising the same as active ingredient
  申请人：Ohmoto Kazuyuki

  公开号：US20050009755A1

  公开（公告）日：2005-01-13

  A benzene-fused heteroring derivative of formula (I) wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of immune diseases (autoimmune diseases, infectious diseases, etc.), inflammatory diseases (inflammatory bowel diseases, multiple cerebrosclerosis, arthritis, etc.), nerve degeneration diseases (Alzheimer's disease, muscular dystrophy, etc.), bone resorption diseases (osteoporosis, etc.), respiratory system diseases, diabetes, shock, etc.

  式(I)的苯并杂环衍生物及其非毒性盐，其中所有符号与说明书中所述相同。式(I)化合物具有对半胱氨酸蛋白酶的抑制活性，因此它可用作预防和/或治疗免疫疾病（自身免疫性疾病、传染病等）、炎症性疾病（炎症性肠病、多发性硬化症、关节炎等）、神经退行性疾病（阿尔茨海默病、肌萎缩症等）、骨吸收性疾病（骨质疏松症等）、呼吸系统疾病、糖尿病、休克等药剂。
• BENZENE-FUSED HETEROCYCLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1254898A1

  公开（公告）日：2002-11-06

  A benzene-fused heteroring derivative of formula (I)    wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of immune diseases (autoimmune diseases, infectious diseases, etc.), inflammatory diseases (inflammatory bowel diseases, multiple cerebrosclerosis, arthritis, etc.), nerve degeneration diseases (Alzheimer's disease, muscular dystrophy, etc.), bone resorption diseases (osteoporosis, etc.), respiratory system diseases, diabetes, shock, etc.

  一种式 (I) 的苯并杂环衍生物 其中所有符号与说明书中所述相同，及其无毒盐。 式（I）化合物对半胱氨酸蛋白酶具有抑制活性，因此可用作预防和/或治疗免疫性疾病（自身免疫性疾病、传染性疾病等）、炎症性疾病（炎症性肠病、多发性脑硬化症、关节炎等）、神经变性疾病（阿尔茨海默病、肌肉萎缩症等）、骨吸收疾病（骨质疏松症等）、呼吸系统疾病、糖尿病、休克等的药物。
• US6809092B2
  申请人：——

  公开号：US6809092B2

  公开（公告）日：2004-10-26
• US7008938B2
  申请人：——

  公开号：US7008938B2

  公开（公告）日：2006-03-07