2,4-Bis-(N-methylphenylamino)pyrido[2.3-d]pyrimidine | 133223-99-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,4-Bis-(N-methylphenylamino)pyrido[2.3-d]pyrimidine
• 英文别名: 2-N,4-N-dimethyl-2-N,4-N-diphenylpyrido[2,3-d]pyrimidine-2,4-diamine
• CAS: 133223-99-1
• 化学式: C₂₁H₁₉N₅
• 分子量: 341.415
• InChiKey: DXVMTXIZDGWAOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  45.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Pyridopyrimidine derivatives, process for the preparation thereof and pharmaceutical compositions containing them
  申请人：SMITHKLINE BEECHAM INTERCREDIT B.V.

  公开号：EP0404355A1

  公开（公告）日：1990-12-27

  Compounds of structure in which A is a pyridyl ring; R1 and R2 are the same, or different and are each hydrogen, C1-4 alkyl, -(CH2)-nAr in which n is 0 to 4 and Ar is an optionally substituted phenyl group, or R' and R2 together with the nitrogen atom to which they are attached form a saturated or unsaturated ring optionally containing one or more further heteroatoms; R3 and R4 are the same or different and are each hydrogen, C1-4alkyl, (CH2)nAr1 in which n is 0 to 4 and Ar' is an optionally substituted phenyl group, or R3 and R4 together with the nitrogen atom to which they are attached form a saturated or unsaturated ring optionally containing one or more further heteroatoms; and R5 is hydrogen or C1-4 alkyl; processes for their preparation, pharmaceutical compositions containing them and their use in therapy as anti-ulcer agents.

  该化合物结构中，A为吡啶环；R1和R2相同或不同，分别为氢、C1-4烷基、-(CH2)-nAr，其中n为0至4，Ar为可选取代的苯基，或者R'和R2与它们所连接的氮原子形成饱和或不饱和环，可选包含一个或多个进一步的杂原子；R3和R4相同或不同，分别为氢、C1-4烷基、( )nAr1，其中n为0至4，Ar'为可选取代的苯基，或者R3和R4与它们所连接的氮原子形成饱和或不饱和环，可选包含一个或多个进一步的杂原子；而R5为氢或C1-4烷基。该化合物的制备方法、含有它们的药物组合物以及它们作为抗溃疡剂的治疗用途。
• JPH0317080A
  申请人：——

  公开号：JPH0317080A

  公开（公告）日：1991-01-25