6-(2-(3-chloro-4-fluorophenylamino)-4-(3-methoxypropylamino)pyrimidin-5-yl)benzo[b]thiophene-2-carboxylic acid-carboxylic acid | 1220130-58-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 6-(2-(3-chloro-4-fluorophenylamino)-4-(3-methoxypropylamino)pyrimidin-5-yl)benzo[b]thiophene-2-carboxylic acid-carboxylic acid
• 英文别名: 5-[2-(3-Chloro-4-fluoroanilino)-4-(3-methoxypropylamino)pyrimidin-5-yl]-1-benzothiophene-2-carboxylic acid
• CAS: 1220130-58-4
• 化学式: C₂₃H₂₀ClFN₄O₃S
• 分子量: 486.954
• InChiKey: LVWTYSGNVHCFAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF
  申请人：Boriack-Sjodin Ann

  公开号：US20100137313A1

  公开（公告）日：2010-06-03

  Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

  本文描述了化学式(I)的化合物及其药学上可接受的盐。还描述了制备它们的过程，包含它们的制药组合物，以及它们作为药物治疗细菌感染的用途。
• [EN] HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF<br/>[FR] DÉRIVÉS HÉTÉROCYCLIQUES ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：ASTRAZENECA AB

  公开号：WO2010038081A2

  公开（公告）日：2010-04-08

  Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.