2-Cyclopropyl-4-nitrophenol | 28987-73-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-Cyclopropyl-4-nitrophenol
• CAS: 28987-73-7
• 化学式: C₉H₉NO₃
• 分子量: 179.175
• InChiKey: WHWXPAICHYDDJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Non-basic melanin concentrating hormone receptor-1 antagonists
  申请人：Washburn N. William

  公开号：US20070093509A1

  公开（公告）日：2007-04-26

  The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.

  本申请提供了按照公式I提供的化合物，包括所有立体异构体、溶剂合物、前药和药学上可接受的形式。此外，本申请提供了含有至少一种按照公式I的化合物和可选的至少一种额外治疗剂的制药组合物。最后，本申请提供了通过给予按照公式I的化合物的治疗有效剂量来治疗患有MCHR-1调节的疾病或疾病，例如肥胖症、糖尿病、抑郁症或焦虑症的患者的方法。
• Thienopyrimidinone derivatives as melanin concentrating hormone receptor-1 antagonists
  申请人：Bristol-Myers Squibb Company

  公开号：EP2298776A1

  公开（公告）日：2011-03-23

  The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula 1.

  本申请提供了根据式 I 的化合物，包括其所有立体异构体、溶解物、原药和药学上可接受的形式。此外，本申请还提供了含有至少一种根据式 I 的化合物和可选的至少一种额外治疗剂的药物组合物。最后，本申请提供了通过施用治疗有效剂量的根据式 1 的化合物来治疗患有 MCHR-1 调节的疾病或紊乱的患者的方法，例如肥胖症、糖尿病、抑郁症或焦虑症。
• THIENOPYRIMIDINONE DERIVATIVES AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1948665A2

  公开（公告）日：2008-07-30
• US8618115B2
  申请人：——

  公开号：US8618115B2

  公开（公告）日：2013-12-31
• [EN] NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR 1 DE L'HORMONE DE CONCENTRATION DE LA MELANINE NON BASIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2007050726A2

  公开（公告）日：2007-05-03

  [EN] The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression or anxiety by administration of a therapeutically effective dose of a compound according to Formula I.
  [FR] L'invention concerne des composés comprenant tous les stéréoisomères, les solvates, les promédicaments et leurs formes pharmaceutiquement acceptables de formule (I). L'invention concerne, de plus, des compositions pharmaceutiques contenant au moins un composé de formule (I) et éventuellement au moins un agent thérapeutique supplémentaire. Enfin, l'invention concerne des méthodes pour traiter un patient souffrant d'une maladie ou des troubles modulés par la MCHR-1, tels que l'obésité, le diabète, la dépression ou l'anxiété comprenant l'administration d'une dose à efficacité thérapeutique du composé de formule (I).