1,5,6-trihydroxy-2-isopropylamino-1,2,3,4-tetrahydronaphthalene | 342399-27-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1,5,6-trihydroxy-2-isopropylamino-1,2,3,4-tetrahydronaphthalene
• 英文别名: 6-(Propan-2-ylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol
• CAS: 342399-27-3
• 化学式: C₁₃H₁₉NO₃
• 分子量: 237.299
• InChiKey: VYPNBBZHLGJXPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4-dihydro-2-isopropylamino-5,6-dihydroxy-1(2H)-naphthalenone hydrobromide 以88%的产率得到
  参考文献：
  名称：

  OKA JOSHIKAZU; MOTOHASHI MICHIO; SUGIHARA HIROSADA; MIYASHITA OSAMU; ITOH+, CHEM. AND PHARM. BULL., 1977, 25, NO 4, 632-639

  摘要：

  DOI：

文献信息

• BETA-2 SELECTIVE ADRENERGIC RECEPTOR AGONISTS
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：EP3720445A1

  公开（公告）日：2020-10-14
• US4041079A
  申请人：——

  公开号：US4041079A

  公开（公告）日：1977-08-09
• [EN] BETA-2 SELECTIVE ADRENERGIC RECEPTOR AGONISTS<br/>[FR] AGONISTES DE RÉCEPTEUR ADRÉNERGIQUE BÊTA-2 SÉLECTIF
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2019112913A1

  公开（公告）日：2019-06-13

  Aspects of the present disclosure include conformationally restricted analogs of catecholamine type compounds (e.g., isoprenaline, adrenaline, noradrenaline) which activate β2AR with high selectivity over β1AR. The subject beta-2 selective adrenergic receptor agonist compounds may serve as bronchiodilators and find use in the treatment of a variety of bronchoconstrictive diseases and conditions. Also provided are compositions and methods for treating preterm labor. A method of treating acute asthma including administration of a subject compound to a subject in need thereof is provided. The subject method can provide for reduced undesirable side effects associated with non-selective β-adrenergic receptor agonism, such as inotropic and chronotropic effects that leads to elevated blood pressure. The compounds can also be used to prevent or treat heart failure. Kits and compositions for practicing the subject methods are also provided.