3-(Furan-2-yl)pyrrolidine | 1082926-03-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(Furan-2-yl)pyrrolidine
• CAS: 1082926-03-1
• 化学式: C₈H₁₁NO
• mdl: MFCD06657905
• 分子量: 137.18
• InChiKey: JZUXVUVOBBUMGK-UHFFFAOYSA-N

物化性质

• 沸点：
  214.9±28.0 °C(Predicted)
• 密度：
  1.041±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  25.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Blood-brain barrier-penetrant dopamine-β-hydroxylase inhibitors
  申请人：BIAL—PORTELA & Cᵃ, S.A.

  公开号：US10975083B2

  公开（公告）日：2021-04-13

  This invention relates to: (a) compounds of formula (I) (with R1 to R5, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.

  本发明涉及：(a) 可用作多巴胺-β-羟化酶抑制剂的式 (I) 化合物（其中 R1 至 R5、n 和 A 如本文所定义）及其药学上可接受的盐或溶液；(b) 包含此类化合物、盐或溶液的药物组合物；(c) 此类化合物、盐或溶液在治疗中的用途；(d) 使用此类化合物、盐或溶液的治疗方法；以及 (e) 用于合成此类化合物的工艺和中间体。
• BLOOD-BRAIN BARRIER-PENETRANT DOPAMINE-B-HYDROXYLASE INHIBITORS
  申请人：BIAL - PORTELA & Cª, S.A.

  公开号：EP3515433A1

  公开（公告）日：2019-07-31
• BLOOD-BRAIN BARRIER-PENETRANT DOPAMINE-ß-HYDROXYLASE INHIBITORS
  申请人：BIAL - PORTELA & CA, S.A.

  公开号：US20220017523A1

  公开（公告）日：2022-01-20

  This invention relates to: (a) compounds of formula I (with R 1 to R 5 , n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.
• US6303593B1
  申请人：——

  公开号：US6303593B1

  公开（公告）日：2001-10-16
• [EN] BLOOD-BRAIN BARRIER-PENETRANT DOPAMINE-B-HYDROXYLASE INHIBITORS<br/>[FR] INHIBITEURS DE DOPAMINE-β-HYDROXYLASE PÉNÉTRANT DANS LA BARRIÈRE HÉMATO-ENCÉPHALIQUE
  申请人：BIAL PORTELA & Cª S A

  公开号：WO2018056854A1

  公开（公告）日：2018-03-29

  This invention relates to: (a) compounds of formula (I) (with R1 to R5, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.