4-(3-bromo-6-chlorobenzofuran-7-ylamino)-6-methoxy-7-(3-morpholinopropoxy)quinazoline | 412349-10-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(3-bromo-6-chlorobenzofuran-7-ylamino)-6-methoxy-7-(3-morpholinopropoxy)quinazoline
• 英文别名: N-(3-bromo-6-chloro-1-benzofuran-7-yl)-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
• CAS: 412349-10-1
• 化学式: C₂₄H₂₄BrClN₄O₄
• 分子量: 547.836
• InChiKey: LDCXVSGWMVTKEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  81.9
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-氯-6-甲氧基-7-[3-(4-吗啉)丙氧基]喹唑啉 、 7-amino-3-bromo-6-chlorobenzofuran 以to give the title compound (0.14 g)的产率得到4-(3-bromo-6-chlorobenzofuran-7-ylamino)-6-methoxy-7-(3-morpholinopropoxy)quinazoline
  参考文献：
  名称：

  Quinazoline derivatives with anti-tumour activity

  摘要：

  本发明涉及公式I中的喹唑啉衍生物，其中m、R1、n、R2和R3中的每一个都具有描述中定义的任何含义；制备它们的过程，包含它们的制药组合物以及它们在制造用于抗侵袭剂的药物，用于包含和/或治疗实体肿瘤疾病的用途。

  公开号：

  US06849625B2

文献信息

• PREPARATION AND USE OF HETEROGENEOUS CATALYST COMPONENTS FOR OLEFINS POLYMERIZATION
  申请人：——

  公开号：US20030144135A1

  公开（公告）日：2003-07-31

  Heterogeneous catalytic component obtainable by reacting a porous inorganic support with a metallocene compound characterized in that the metallocene compound is defined by the following general formulas: (LR k ) z [LR k-f (R I OH) f ] x MX y I 1 wherein: L, equal to or different from each other, is selected from the group comprising: cyclopentadienyl, indenyl, tetrahydroindenyl, fluorenyl, octahydrofluorenyl or benzoindenyl; each R is independently selected from hydrogen, C 1 -C 20 alkyl, C 3 -C 20 cycloalkyl, C 6 -C 20 aryl, C 3 -C 20 alkenyl, C 7 -C 20 arylalkyl, C 7 -C 20 alkylaryl, C 8 -C 20 arylalkenyl, linear or branched, optionally substituted by 1 to 10 halogen atoms, or a group SiR II 3 ; each R I equal to or different from each other is a divalent aliphatic or aromatic hydrocarbon group containing from 1 to 20 carbon atoms, optionally containing from 1 to 5 heteroatoms of groups 14 to 16 of the periodic table of the elements and boron; each Q is independently selected from B, C, Si, Ge, Sn; M is a metal of group 3, 4 or 10 of the Periodic Table, Lanthanide or Actinide; each X is independently selected from: hydrogen, chlorine, bromine, OR II , NR II 2 , C 1 -C 20 alkyl or C 6 -C 20 aryl; each R II is independently selected from C 1 -C 20 alkyl, C 3 -C 20 cycloalkyl, C 6 -C 20 aryl, C 3 -C 20 alkenyl, C 7 -C 20 arylalkyl, C 7 -C 20 arylalkenyl or alkylaryl, linear or branched; R II is methyl, ethyl, isopropyl; L′ is N or O; when L is cyclopentadienyl k is equal to 5, when L is indenyl k is equal to 7, when L is fluorenyl or benzoindenyl k is equal to 9, when L is tetrahydroindenyl k is equal to 11 and when L is octahydrofluorenyl, k is equal to 17; z is equal to 0, 1 or 2; x is equal to 1, 2 or 3; y is equal to 1, 2 or 3; x+y+z is equal to the valence of M; m is an integer which can assume the values 1, 2, 3 or 4; a and b are integers whose value ranges from 0 to k−1; f is an integer whose value ranges from 1 to k; g is 0 or 1; c and e are equal to 0 or 1; a+b+c is at least 1; a+g+c is at least 1; d is equal to 0, 1 or 2; when Q is B, then c+d=1; when Q is C, Si, Ge or Sn, then c+d=2; when L′ is N, then g+e=1; when L′ is O, then g=0 and e=0.

  通过将多孔无机支撑物与金属茂反应得到的异质催化组分，其特征在于所述金属茂由以下通式定义：(LRk)z[LRk-f(RIOH)f]xMXyI1其中：L，相同或不同，选自环戊二烯基，茚基，四氢茚基，芴基，八氢芴基或苯并茚基的群体；每个R独立选自氢，C1-C20烷基，C3-C20环烷基，C6-C20芳基，C3-C20烯基，C7-C20芳基烷基，C7-C20烷基芳基，C8-C20芳基烯基，线性或支链，可选地被1至10个卤原子取代，或SiRII3基团；每个RI相同或不同，是含有1至20个碳原子的二价脂肪族或芳香族碳氢基团，可选地含有元素周期表14至16组和硼的1至5个杂原子；每个Q独立选自B、C、Si、Ge、Sn；M是元素周期表3、4或10组的金属，镧系元素或锕系元素；每个X独立选自：氢、氯、溴、ORII、NRII2、C1-C20烷基或C6-C20芳基；每个RII独立选自C1-C20烷基，C3-C20环烷基，C6-C20芳基，C3-C20烯基，C7-C20芳基烷基，C7-C20芳基烯基或烷基芳基，线性或支链；RII是甲基、乙基、异丙基；L'是N或O；当L为环戊二烯基时，k等于5，当L为茚基时，k等于7，当L为芴基或苯并茚基时，k等于9，当L为四氢茚基时，k等于11，当L为八氢芴基时，k等于17；z等于0、1或2；x等于1、2或3；y等于1、2或3；x+y+z等于M的化合价；m是可以取1、2、3或4的整数；a和b是整数，其值范围从0到k-1；f是整数，其值范围从1到k；g为0或1；c和e等于0或1；a+b+c至少为1；a+g+c至少为1；d等于0、1或2；当Q为B时，c+d=1；当Q为C、Si、Ge或Sn时，c+d=2；当L'为N时，g+e=1；当L'为O时，g=0且e=0。
• Preparation and use of heterogeneous catalyst components for olefins polymerization
  申请人：Llinas Hidalgo Gerardo

  公开号：US20050065018A1

  公开（公告）日：2005-03-24

  Heterogeneous catalytic component obtainable by reacting a porous inorganic support with a metallocene compound characterized in that the metallocene compound is defined by the following general formulas: wherein: L, equal to or different from each other, is selected from the group comprising: cyclopentadienyl, indenyl, tetrahydroindenyl, fluorenyl, octahydrofluorenyl or benzoindenyl; each R is independently selected from hydrogen, C 1 -C 20 alkyl, C 3 -C 20 cycloalkyl, C 6 -C 20 aryl, C 3 -C 20 alkenyl, C 7 -C 20 arylalkyl, C 7 -C 20 alkylaryl, C 8 - 20 arylalkenyl, linear or branched, optionally substituted by 1 to 10 halogen atoms, or a group SiR II 3 ; each R I equal to or different from each other is a divalent aliphatic or aromatic hydrocarbon group containing from 1 to 20 carbon atoms, optionally containing from 1 to 5 heteroatoms of groups 14 to 16 of the periodic table of the elements and boron; each Q is independently selected from B, C, Si, Ge, Sn; M is a metal of group 3, 4 or 10 of the Periodic Table, Lanthanide or Actinide; each X is independently selected from: hydrogen, chlorine, bromine, OR II , NR II 2 , C 1 -C 20 alkyl or C 6 -C 20 aryl; each R II is independently selected from C 1 -C 20 alkyl , C 3 -C 20 cycloalkyl, C 6 -C 20 aryl, C 3 -C 20 alkenyl C 7 -C 20 arylalkyl, C 7 -C 20 arylalkenyl or alkylaryl, linear or branched; R II is methyl, ethyl isopropyl; L′ is N or O; when L is cyclopentadienyl k is equal to 5, when L is indenyl k is equal to 7, when L is fluorenyl or benzoindenyl k is equal to 9, when L is tetrahydroindenyl k is equal to 11 and when L is octahydrofluorenyl, k is equal to 17; z is equal to 0, 1 or 2; x is equal to 1, 2 or 3; y is equal to 1, 2 or 3; x+y+z is equal to the valence of M; m is an integer which can assume the values 1, 2, 3 or 4; a and b are integers whose value ranges from 0 to k-1; f is an integer whose value ranges from 1 to k; g is 0 or 1; c and e are equal to 0 or 1; a+b+c is at least 1; a+g+c is at least 1; d is equal to 0, 1 or 2; when Q is B, then c+d=1; when Q is C, Si, Ge or Sn, then c+d=2; when L′ is N, then g+e=1; when L′ is O, then g=0 and e=0.

  通过将多孔无机支撑物与金属茂化合物反应而得到的异质催化组分，其特征在于所述金属茂化合物由以下一般公式定义： 其中： L，相等或不同，选自包括环戊二烯基、茚基、四氢茚基、芴基、八氢芴基或苯并茚基的群体； 每个R独立地选自氢、C1-C20烷基、C3-C20环烷基、C6-C20芳基、C3-C20烯基、C7-C20芳基烷基、C7-C20烷基芳基、C8-20芳基烯基、线性或支链，可选地被1到10个卤素原子取代，或者是SiRII3基团； 每个RI相等或不同，是一个含有1到20个碳原子的二价脂肪族或芳香族碳氢基团，可选地含有周期表14到16组和硼的1到5个杂原子； 每个Q独立地选自B、C、Si、Ge、Sn； M是周期表3、4或10组的金属、镧系元素或锕系元素； 每个X独立地选自：氢、氯、溴、ORII、NRII2、C1-C20烷基或C6-C20芳基； 每个RII独立地选自C1-C20烷基、C3-C20环烷基、C6-C20芳基、C3-C20烯基、C7-C20芳基烷基、C7-C20芳基烯基或烷基芳基，线性或支链； RII是甲基、乙基或异丙基； L'是N或O；当L为环戊二烯基时，k等于5，当L为茚基时，k等于7，当L为芴基或苯并茚基时，k等于9，当L为四氢茚基时，k等于11，当L为八氢芴基时，k等于17； z等于0、1或2； x等于1、2或3； y等于1、2或3； x+y+z等于M的价； m是可以取值为1、2、3或4的整数； a和b是值在0到k-1之间的整数； f是值在1到k之间的整数； g等于0或1； c和e等于0或1； a+b+c至少为1； a+g+c至少为1； d等于0、1或2；当Q为B时，c+d=1；当Q为C、Si、Ge或Sn时，c+d=2；当L'为N时，g+e=1；当L'为O时，g=0且e=0。
• Functionalized metallocene compounds, synthesis process and use thereof
  申请人：REPSOL QUIMICA S.A.

  公开号：EP0955306B1

  公开（公告）日：2003-01-22
• QUINAZOLINE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY
  申请人：AstraZeneca AB

  公开号：EP1326859A1

  公开（公告）日：2003-07-16
• US6114555A
  申请人：——

  公开号：US6114555A

  公开（公告）日：2000-09-05