3-ethyl-7-[(4-fluorophenyl)-imidazol-1-ylmethyl]-1H-quinoxalin-2-one | 854398-32-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-ethyl-7-[(4-fluorophenyl)-imidazol-1-ylmethyl]-1H-quinoxalin-2-one
• CAS: 854398-32-6
• 化学式: C₂₀H₁₇FN₄O
• 分子量: 348.38
• InChiKey: ISVWKFBUAJEDJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  59.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 7-Phenylalkyl Substituted 2-Quinolinones and 2-Quinoxalinones as Poly(Adp-Ribose) Polymerase Inhibitors
  申请人：Mabire Dominique Jean-Pierre

  公开号：US20080249099A1

  公开（公告）日：2008-10-09

  The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and X have defined meanings.
• 7-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS
  申请人：Mabire Dominique Jean-Pierre

  公开号：US20110230492A1

  公开（公告）日：2011-09-22

  The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and X have defined meanings.
• US7928104B2
  申请人：——

  公开号：US7928104B2

  公开（公告）日：2011-04-19
• US8524714B2
  申请人：——

  公开号：US8524714B2

  公开（公告）日：2013-09-03