2-[(2-{3-[(1H-imidazol-2-ylmethyl)-amino]-phenyl}-ethyl)-methyl-amino]-6,7-dimethoxy-1H-quinazolin-4-one | 828242-23-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-[(2-{3-[(1H-imidazol-2-ylmethyl)-amino]-phenyl}-ethyl)-methyl-amino]-6,7-dimethoxy-1H-quinazolin-4-one
• 英文别名: 2-[2-[3-(1H-imidazol-2-ylmethylamino)phenyl]ethyl-methylamino]-6,7-dimethoxy-3H-quinazolin-4-one
• CAS: 828242-23-5
• 化学式: C₂₃H₂₆N₆O₃
• 分子量: 434.498
• InChiKey: LBQGHBAUPVRDSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists
  申请人：Connolly Joseph Terrence

  公开号：US20050038016A1

  公开（公告）日：2005-02-17

  Compounds represented by Formula I: which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R′, R 5 and R 10 are as defined herein.

  公式I所代表的化合物，可用作α-1A/B肾上腺素受体拮抗剂，用于治疗与α-1A/B肾上腺素受体活性相关的疾病的方法，以及制备所述化合物的方法，其中Ar、Z、R、R′、R5和R10如本文所定义。
• ARYLAMINE-SUBSTITUTED QUINAZOLINONE COMPOUNDS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1644369A2

  公开（公告）日：2006-04-12
• US7244738B2
  申请人：——

  公开号：US7244738B2

  公开（公告）日：2007-07-17
• [EN] ARYLAMINE-SUBSTITUTED QUINAZOLINONE COMPOUNDS<br/>[FR] COMPOSES DE QUINAZOLINONE SUBSTITUES PAR ARYLAMINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005005395A2

  公开（公告）日：2005-01-20

  Compounds represented by Formula (I) which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R', R5 and R10 are as defined herein.