(2R)-2-Amino-3-butoxy-1-propanol | 475599-06-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2R)-2-Amino-3-butoxy-1-propanol
• 英文别名: (2R)-2-amino-3-butoxypropan-1-ol
• CAS: 475599-06-5
• 化学式: C₇H₁₇NO₂
• 分子量: 147.217
• InChiKey: JQYRKRFIRMWQIV-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMPOUNDS
  申请人：Alemparte-Gallardo Carlos

  公开号：US20090306089A1

  公开（公告）日：2009-12-10

  Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof: (relative chemistry shown) pharmaceutical compositions comprising them, their use in therapy especially against tuberculosis, and methods of preparing them are described.

  公式(I)的化合物或其药用可接受的盐或N-氧化物，(相对化学显示)包含它们的药物组合物，它们在治疗中的用途特别是针对结核病，以及制备它们的方法被描述。
• [EN] TRICYCLIC NITROGEN CONTAINING COMPOUNDS AND THEIR USE AS ANTIBACTERIALS<br/>[FR] COMPOSÉS CONTENANT DE L'AZOTE TRICYCLIQUE ET UTILISATION DE CEUX-CI COMME ANTIBACTÉRIENS
  申请人：GLAXO GROUP LTD

  公开号：WO2009141399A1

  公开（公告）日：2009-11-26

  Compounds of Formula (I) or a pharmaceutically acceptable salt or N-oxide thereof; Formula (I) (relative stereochemistry shown) wherein: Z1, Z2 , L are as defined, U represents a cyclic group selected from: phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, furanyl, imidazolyl and thiophenyl; m is 0 or 1, n is independently 0 or 1; and substituent(s) R5 and R6 are independently selected from: halo, CF3, OCF3, C1_3 alkyl, C1_3 alkoxy, nitro and cyano. Compounds of Formula (I) have anti -tuberculosis and antibacterial activity.

  化合物的结构式（I）或其药学上可接受的盐或N-氧化物；结构式（I）（显示相对立体化学）其中：Z1、Z2、L如定义，U代表从中选择的环状基团：苯基、吡啶基、吡啶并嗪基、嘧啶基、吡嗪基、噻唑基、呋喃基、咪唑基和噻吩基；m为0或1，n独立为0或1；取代基R5和R6独立选择自：卤素、三氟甲基、三氟甲氧基、C1_3烷基、C1_3烷氧基、硝基和氰基。结构式（I）的化合物具有抗结核和抗菌活性。
• Alkylamide compounds
  申请人：Pfizer Inc.

  公开号：US20030105097A1

  公开（公告）日：2003-06-05

  The invention provides compounds of formula (I) 1 wherein R 1 is optionally substituted C 1-6 alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, C 1-6 alkoxy, —NR 2 R 3 or —NR 4 SO 2 R 5 ; n is 2 to 6; X is oxygen, sulfur or —CH 2 —; Y is C 1-6 alkyl which may be branched- or straight-chain, and may be independently substituted by one or more halo, C 1-4 alkoxy, hydroxy or C 3-7 cycloalkyl; wherein the linkage —(CH 2 ) n — and the linkage when X is —CH 2 —, may be substituted by C 1-4 alkyl, C 1-4 haloalkyl, hydroxy, C 1-4 alkoxy, C 1-4 haloalkoxy, hydroxyC 1-4 alkyl, C 1-4 alkoxyC 1-4 alkyl, C 1-4 haloalkoxyC 1-4 alkyl, C 3-7 cycloalkyl or C 3-7 cycloalkylC 1-4 alkyl. The compounds of the invention are useful in the treatment of sexual dysfunction, particularly female sexual dysfunction.

  本发明提供了公式（I）的化合物，其中R1是可选的取代C1-6烷基，可选的取代的碳环烷基，可选的取代的杂环烷基，C1-6烷氧基，-NR2R3或-NR4SO2R5; n为2到6; X为氧、硫或-CH2-; Y为C1-6烷基，可以是分支或直链，可以独立地被一个或多个卤素、C1-4烷氧基、羟基或C3-7环烷基取代; 其中链-（ ）n-和链当X为- -时，可以被C1-4烷基、C1-4卤代烷基、羟基、C1-4烷氧基、C1-4卤代烷氧基、羟基C1-4烷基、C1-4烷氧基C1-4烷基、C1-4卤代烷氧基C1-4烷基、C3-7环烷基或C3-7环烷基C1-4烷基取代。本发明的化合物可用于治疗性功能障碍，特别是女性性功能障碍。
• [EN] TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION<br/>[FR] COMPOSÉS CONTENANT DE L'AZOTE TRICYCLIQUE POUR LE TRAITEMENT DE L'INFECTION À NEISSERIA GONORRHOEAE
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2016027249A1

  公开（公告）日：2016-02-25

  The present invention relates to methods for treating Neisseria gonorrhoeae infection which comprises administering to a subject in need thereof novel Tricyclic nitrogen containing compounds and corresponding pharmaceutical compositions as described herein.

  本发明涉及一种治疗淋病奈瑟氏菌感染的方法，包括向需要该方法的受试者施用本文所述的新型三环氮含量化合物及相应的药物组成。
• TRICYCLIC NITROGEN CONTAINING COMPOUNDS AS ANTIBACTERIAL AGENTS
  申请人：Davies David Evan

  公开号：US20100137282A1

  公开（公告）日：2010-06-03

  Tricyclic nitrogen containing compounds and their use as antibacterials. Z 1 and Z 2 are independently selected from CH and N.

  三环氮含化合物及其作为抗菌剂的用途。Z1和Z2分别选择自CH和N。