4-chloro-2-(1H-imidazol-1-yl)-6-(piperidin-1-yl)pyrimidine | 212649-60-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-chloro-2-(1H-imidazol-1-yl)-6-(piperidin-1-yl)pyrimidine
• 英文别名: 4-Chloro-2-imidazol-1-yl-6-piperidin-1-ylpyrimidine
• CAS: 212649-60-0
• 化学式: C₁₂H₁₄ClN₅
• 分子量: 263.73
• InChiKey: FBCOPXKJAQMYIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  46.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Preformed multi-acid adducts useful for grafting polyolefin polymers
  申请人：——

  公开号：US20010007001A1

  公开（公告）日：2001-07-05

  The present invention relates to reaction products formed from maleic anhydride and amino carboxylic acids. The reaction products are particularly useful for grafting polyolefins to increase their polarity and therefore enhance their physical properties.

  本发明涉及由马来酸酐和氨基羧酸形成的反应产物。该反应产物特别适用于将聚烯烃接枝以增加其极性，从而增强其物理性能。
• N-heterocyclic derivatives as NOS inhibitors
  申请人：Berlex Laboratories, Inc.

  公开号：US20020183323A1

  公开（公告）日：2002-12-05

  N-Heterocyclic derivatives of the formula (I): 1 are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

  本文描述了公式（I）中的N-杂环衍生物1，以及其他N-杂环，作为一氧化氮合酶的抑制剂。本文还描述了含有这些化合物的制药组合物，使用这些化合物作为一氧化氮合酶抑制剂的方法，以及合成这些化合物的过程。
• PROCESS FOR PRODUCING GRAFT POLYOLEFIN
  申请人：KAWASAKI STEEL CORPORATION

  公开号：EP0713891A1

  公开（公告）日：1996-05-29

  When producing a graft modified polyolefin by melting and kneading a polyolefin, a radical-polymerizable monomer and a radical-polymerization initiator, the producing efficiency is improved. The grafting reaction is effected by feeding the melted polyolefin containing either one of said radical-polymerizable monomer and the radical-polymerization initiator to the other. When said radical-polymerizable monomer is an unsaturated carboxylic anhydride, said unsaturated carboxylic anhydride as a starting material is preliminarily heated at 50 to 250°C, and then fed to the grafting reaction mentioned above. When the monomer is an unsaturated carboxylic acid or an acid anhydride of such an unsaturated carboxylic acid, an organic peroxide of a formula (I) is used as the radical-polymerization initiator.    In this formula (I), two substituting groups connected directly to the benzene ring have an ortho-positional relationship or a meta-positional relationship, R₁, R₂, R₃, R₄, R₅ and R₆ ,which are the same as or different from one another, each denote a hydrogen atom or an alkyl group having the number of carbons of 1 to 10.

  通过熔化和捏合聚烯烃、可自由基聚合的单体和自由基聚合引发剂来生产接枝改性聚烯烃，可提高生产效率。接枝反应是通过将含有所述可自由基聚合单体和自由基聚合引发剂中的任一种的熔融聚烯烃喂入另一种聚烯烃来实现的。当所述可自由基聚合单体为不饱和羧酸酐时，将所述不饱和羧酸酐作为起始原料在 50 至 250°C 下初步加热，然后送入上述接枝反应中。当单体为不饱和羧酸或不饱和羧酸的酸酐时，使用式（I）的有机过氧化物作为自由基聚合引发剂。 在该式（I）中，与苯环直接相连的两个取代基具有正交位置关系或偏交位置关系，R₁、R₂、R₃、R₄、R₅ 和 R₆（它们彼此相同或不同）分别表示氢原子或碳原子数为 1 至 10 的烷基。
• N-Heterocyclic derivatives as nos inhibitors
  申请人：Berlex, Inc.

  公开号：EP1754703A2

  公开（公告）日：2007-02-21

  N-Heterocyclic derivatives of formula (I) are described herein, as well as other N-Heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

  本文描述了作为一氧化氮合酶抑制剂的式 (I) N-杂环衍生物以及其他 N-杂环。本文还描述了含有这些化合物的药物组合物、使用这些化合物作为一氧化氮合酶抑制剂的方法以及合成这些化合物的工艺。
• N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS
  申请人：BERLEX LABORATORIES, INC.

  公开号：EP0968206A1

  公开（公告）日：2000-01-05