5-Chloro-N-(1-methylethyl)-6-[4-(2-oxo-1,3-benzoxazol-3(2H)-yl)piperidin-1-yl]pyridine-3-carboxamide | 345583-55-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 5-Chloro-N-(1-methylethyl)-6-[4-(2-oxo-1,3-benzoxazol-3(2H)-yl)piperidin-1-yl]pyridine-3-carboxamide
• 英文别名: 5-chloro-6-[4-(2-oxo-1,3-benzoxazol-3-yl)piperidin-1-yl]-N-propan-2-ylpyridine-3-carboxamide
• CAS: 345583-55-3
• 化学式: C₂₁H₂₃ClN₄O₃
• 分子量: 414.892
• InChiKey: FFGAXQHJVIRERA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  74.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• P2x7 receptor antagonists for use in the treatment of inflammatory, immune or cardiovascular diseases
  申请人：——

  公开号：US20030040513A1

  公开（公告）日：2003-02-27

  The invention provides piperidine compounds of general formula (I) in which A, B, X, Y, Z, R, R 1 and R 2 are as defined in the specification, their use as medicaments, compositions containing them and processes for their for their preparation.

  该发明提供了一般式（I）中的哌啶化合物，其中A、B、X、Y、Z、R、R1和R2如规范中所定义，它们的用途作为药物、含有它们的组合物以及它们的制备方法。
• NEW P2X 7 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF INFLAMMATORY, IMMUNE OR CARDIOVASCULAR DISEASES
  申请人：AstraZeneca AB

  公开号：EP1242396A1

  公开（公告）日：2002-09-25
• US6812226B2
  申请人：——

  公开号：US6812226B2

  公开（公告）日：2004-11-02
• [EN] NEW P2X7 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF INFLAMMATORY, IMMUNE OR CARDIOVASCULAR DISEASES<br/>[FR] NOUVEAUX ANTAGONISTES DES RECEPTEURS P2X7 UTILES DANS LE TRAITEMENT DE MALADIES INFLAMMATOIRES, IMMUNITAIRES OU CARDIOVASCULAIRES
  申请人：ASTRAZENECA AB

  公开号：WO2001044213A1

  公开（公告）日：2001-06-21

  The invention provides piperidine compounds of general formula (I) in which A, B, X, Y, Z, R, R?1 and R2¿ are as defined in the specification, their use as medicaments, compositions containing them and processes for their for their preparation.