1-methyl-hex-2-ynylamine | 98435-28-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-methyl-hex-2-ynylamine
• 英文别名: 2-Amino-hept-3-in；1-Methyl-hex-2-inylamin；Hept-3-yn-2-amine
• CAS: 98435-28-0
• 化学式: C₇H₁₃N
• mdl: MFCD19216763
• 分子量: 111.187
• InChiKey: GDNKTSPKJOEPDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (S)-3-丁炔-2-胺 、 溴丙烷 在 氨 、 sodium amide 作用下， 生成 1-methyl-hex-2-ynylamine
  参考文献：
  名称：

  Marszak-Fleury, Annales de Chimie (Cachan, France), 1958, vol. <13>3, p. 656,676

  摘要：

  DOI：

文献信息

• [EN] TERT-BUTYL (S)-2-(4-(PHENYL)-6H-THIENO[3,2-F][1,2,4]TRIAZOLO[4,3-A] [1,4]DIAZEPIN-6-YL) ACETATE DERIVATIVES AND RELATED COMPOUNDS AS BROMODOMAIN BRD4 INHIBITORS FOR TREATING CANCER<br/>[FR] DÉRIVÉS DE TERT-BUTYL (S)-2-(4-(PHÉNYL)-6H-THIÉNO[3,2-F][1,2,4]TRIAZOLO[4,3-A] [1,4]DIAZÉPIN-6-YL) ACÉTATE ET COMPOSÉS APPARENTÉS UTILISÉS EN TANT QU'INHIBITEURS DE BROMODOMAINE BROMOD4 POUR LE TRAITEMENT DU CANCER
  申请人：GENENTECH INC

  公开号：WO2020055976A1

  公开（公告）日：2020-03-19

  The present disclosure relates to te rt-butyl (S)-2-(4-(phenyl)-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [l,4]diazepin-6-yl) acetate derivatives and related compounds as bromodomain BRD4 inhibitors for treating cancer. Exemplary compounds are e.g. tert-butyl (S)-2-(4-(4-(3-aminoprop-l-yn-l-yl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)acetate (example 1, compound la), tert-butyl(S,E)-2-(4-(4-(3-aminoprop-l-en-l-yl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a][l,4]diazepin-6-yl)acetate (example 6, compound 6a) or tert-butyl(S)-2-(4-(4-(3-(hydroxyamino)prop-l-yn-l-yl)phenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][l,2,4]triazolo[4,3-a] [l,4]diazepin-6-yl)acetate (example 8, compound 8a).Results of biological assays, such as e.g. BRD4 BD1 and BD2 binding (table 2), cell proliferation assays (table 6) and inhibition of MYC expression in MV-4-11 cells (table 7) are disclosed.

  本公开涉及对叔丁基(S)-2-(4-(苯基)-6H-噻吩[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂蒽啉-6-基)醋酸酯衍生物及相关化合物作为治疗癌症的溴结构域BRD4抑制剂。示例化合物包括叔丁基(S)-2-(4-(4-(3-氨基丙-1-炔-1-基)苯基)-2,3,9-三甲基-6H-噻吩[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂蒽啉-6-基)醋酸酯（示例1，化合物la）、叔丁基(S,E)-2-(4-(4-(3-氨基丙-1-烯-1-基)苯基)-2,3,9-三甲基-6H-噻吩[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂蒽啉-6-基)醋酸酯（示例6，化合物6a）或叔丁基(S)-2-(4-(4-(3-(羟胺基)丙-1-炔-1-基)苯基)-2,3,9-三甲基-6H-噻吩[3,2-f][1,2,4]三唑并[4,3-a][1,4]二氮杂蒽啉-6-基)醋酸酯（示例8，化合物8a）。公开了生物测定的结果，例如BRD4 BD1和BD2结合（表2）、细胞增殖测定（表6）以及在MV-4-11细胞中MYC表达的抑制（表7）。
• AMPHIPHILIC POLYMER AND PROCESSES OF FORMING THE SAME
  申请人：Janczewski Dominik

  公开号：US20100298504A1

  公开（公告）日：2010-11-25

  Disclosed are an amphiphilic polymer, its synthesis and uses thereof. The polymer has a hydrocarbon backbone with —COOH side groups. It further has first aliphatic moieties with a main chain of about 3 to about 20 carbon atoms and 0 to about 3 heteroatoms, and second aliphatic moieties that have a main chain of about 3 to about 80 carbon atoms and about 2 to about 40 heteroatoms. The second aliphatic moieties have a copolymerisable group. In the synthesis a maleic anhydride polymer of formula (I) where n is an integer from about 10 to about 10000 and R1 is H or methyl, is reacted with a monofunctional compound with an alkyl chain of about 3 to about 20 carbon atoms and 0 to about 2 heteroatoms, and with an at least bifunctional compound with an alkyl chain of about 3 to about 80 carbon atoms and 0 to about 40 heteroatoms. The functional group of the monofunctional compound and one functional group of the at least bifunctional compound can form a linkage with an anhydride. Another functional group of the at least bifunctional compound, which is not allowed to react with the maleic anhydride polymer, is copolymerisable.