(+/-)-N,N-Dimethyl-α-(4-pyridyl)-ethylamin | 50635-53-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (+/-)-N,N-Dimethyl-α-(4-pyridyl)-ethylamin
• 英文别名: N,N-dimethyl-1-pyridin-4-ylethanamine
• CAS: 50635-53-5
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: PNPMGTBIYMZUPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] 5'-SUBSTITUTED BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM<br/>[FR] NUCLÉOSIDES BICYCLIQUES 5'-SUBSTITUÉS ET COMPOSÉS OLIGOMÈRES SYNTHÉTISÉS À PARTIR DESDITS NUCLÉOSIDES
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2011115818A1

  公开（公告）日：2011-09-22

  Provided herein are novel 5'-(S)-CH3 substituted bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, the furanose ring of each of the novel 5'-(S)-CH3 substituted bicyclic nucleosides includes a 2' to 4' bridging group. The 5'-(S)-CH3 substituted bicyclic nucleosides are expected to be useful for enhancing one or more properties of the oligomeric compounds they are incorporated into such as for example increasing the binding affinity. In certain embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

  本文提供了新颖的5'-(S)-CH3取代的双环核苷，以及由其制备的寡聚化合物和使用这些寡聚化合物的方法。更具体地，每个新颖的5'-(S)- 取代的双环核苷的呋喃糖环包括一个2'到4'的桥联基团。预计这些5'-(S)- 取代的双环核苷将有助于增强它们所并入的寡聚化合物的一个或多个性质，例如增加结合亲和力。在某些实施例中，本文提供的寡聚化合物与靶RNA的部分杂交，导致靶RNA的正常功能丧失。
• 6-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS
  申请人：Swayze E. Eric

  公开号：US20070249049A1

  公开（公告）日：2007-10-25

  The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.

  本发明提供了6-修饰的双环核苷类似物和包含这些核苷类似物的寡聚化合物。在优选实施例中，核苷类似物在6位点具有(R)或(S)-手性。这些双环核苷类似物对提高包括核酸酶抗性在内的寡聚化合物的性能是有用的。
• 5'-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS
  申请人：Isis Pharmaceuticals, Inc.

  公开号：EP2066684B1

  公开（公告）日：2012-07-18
• 6-modified bicyclic nucleic acid analogs
  申请人：Isis Pharmaceuticals, Inc.

  公开号：EP2314594B1

  公开（公告）日：2014-07-23
• SUBSTITUTED ALPHA-L-BICYCLIC NUCLEOSIDES
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP2356129A1

  公开（公告）日：2011-08-17