(1-Naphthalen-1-yl-ethyl)-[1-phenyl-meth-(E)-ylidene]-amine | 144661-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (1-Naphthalen-1-yl-ethyl)-[1-phenyl-meth-(E)-ylidene]-amine
• CAS: 144661-24-5
• 化学式: C₁₉H₁₇N
• 分子量: 259.351
• InChiKey: VUPXNRJHURLJGC-XSFVSMFZSA-N

物化性质

• 沸点：
  409.6±24.0 °C(Predicted)
• 密度：
  1.01±0.1 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  (1-Naphthalen-1-yl-ethyl)-[1-phenyl-meth-(E)-ylidene]-amine 、 3-溴丙烯 在 indium 作用下， 以 四氢呋喃 为溶剂， 反应 36.0h， 以13%的产率得到(1-Naphthalen-1-yl-ethyl)-(1-phenyl-but-3-enyl)-amine
  参考文献：
  名称：

  Indium-mediated allylation of aldimines

  摘要：

  Aldimines are allylated under simple Barbier type conditions using allyl bromide and indium powder in THF.

  DOI：

  10.1016/s0040-4039(00)61099-7

文献信息

• A New Synthesis of α-Amino Acid Thioesters by Pummerer Reaction of 3-Substituted-4-sulfinyl-β-sultams
  作者：Tetsuo Iwama、Tadashi Kataoka、Osamu Muraoka、Genzoh Tanabe

  DOI：10.1021/jo981230n

  日期：1998.11.1

  alpha-Amino acid thioesters were synthesized by the Pummerer reaction of 3-substituted-4-sulfinyl-beta-sultams with TFAA. The 3-substituted-4-sulfinyl-beta-sultams were prepared from the corresponding beta-sultams by sulfenylation with diphenyl disulfide followed by m-CPBA oxidation. Diastereoselective synthesis of beta-sultams by 1,3-asymmetric induction in [2 + 2] cycloaddition of a sulfene intermediate and chiral imines in solution-phase was studied, and it was found that N-alkylimines gave better diastereoselectivities than N-aralkylimines. The use of imines derived from (R)- and (S)-alpha-methylbenzylamine followed by separation of the major and minor diastereomers gave enantiopure 3-substituted-N-methylbenzyl-beta-sultams. These beta-sultams were then converted to N-methylbenzyl-alpha-amino acid thioesters via sulfenylation and Pummerer rearrangement with high or complete retention of configuration.
• A NEW METHOD FOR THE PREPARATION OF CINACALCET AND NEW INTERMEDIATES THEREOF
  申请人：Megafine Pharma (P) Ltd.

  公开号：EP2406211B1

  公开（公告）日：2018-06-27